帕利哌酮緩釋片聯(lián)合氯氮平對(duì)難治性精神分裂癥患者認(rèn)知功能及腦電圖參數(shù)的影響

打開(kāi)文本圖片集

[Abstract]Objective：To investigate the clinical application effct ofcombined treatment withPaliperidone Extended-Release Tablets and Clozapine in patients with treatment-resistant schizophrenia （TRS）.Method： Sixtypatientswith TRSwho visitedthe Departmentof Psychiatryof the Third People'sHospitalofYichun from January1，2O21 to December31，2O23 were selectedand divided into the reference group （30 cases）and the treatment group （3O cases） by random sampling method.The reference group was treated with Clozapine， while the treatment group was treated withPaliperidone Extended-Release Tablets combined with Clozapine.Clinical effcacy，the positive and negativesyndrome scale （PANSS）scores，inflammatory factor levels，cognitive function， and electroencephalogram （EEG） parameters were compared between the two groups. Adverse reactions that occurred during treatment was recorded.Result： The total effective rate in the treatment group was 93.33% （28/30）， which was higher than 73.33% （22/30） in the reference group （ P <0.05）.After 3 months of treatment， the scores of each dimension of PANSS inboth groups decreased，and the scores of the treatment group were lower than those of the reference group （ P <0.05）; the levelsof TNF- α ，IL-6，and IL-2 in both groups decreased，and those in the treatment group were lower than those in the reference group （ P <0.05）; the scores of each dimension of the MATRICS consensuscognitive battery （MCCB）in both groups significantlyincreased，and those in thetreatment group were significantly higher than those in the reference group （ P <0.05）; the EEG parameters of both groups improved，and those in the treatment group were better than those in the reference group （ P <0.05）; during the treatment period，there wasno statisticallysignificant diference intheoccurrence of adversereactions between the two groups P>0.05 ）.Conclusion：Paliperidone Extended-Release Tablets combined with Clozapine can significantly improve clinical effect in treating TRS，aleviate psychiatric symptoms，reduce inflammatoryreactions， and improve cognitive function and brain function in patients.

[KeyWords] Treatment-resistant schizophrenia Clozapine Paliperidone Extended-Release Tablets Cognitive function EEG parameters

First-author'saddress：DepartmentofPsychiatry，theThirdPeople'sHospitalofYichun，Yichun 336000， China

doi：10.3969/j.issn.1674-4985.2025.21.008

精神分裂癥（schizophrenia，SZ）是一種以患者基本個(gè)性的轉(zhuǎn)變，思維、情感及行為的斷裂，以及其精神活動(dòng)與外界環(huán)境之間存在顯著的失調(diào)為特征的精神障礙[]。（剩余5705字）