依托咪酯聯(lián)合丙泊酚全憑靜脈麻醉維持對老年患者硬質氣管鏡介人治療的影響

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[Abstract]Objective： To investigate the effect and safetyof total intravenous anesthesia maintenance with Etomidate combined with Propofol on interventional therapy of rigid bronchoscopy in elderly patients.Method：A totalof124patientswhounderwentinterventionaltherapyofrigidbronchoscopyintheSecondAfiliated Hospitalof XiamenMedical CollgefromDecember 2O22 to June 2O24 wererandomlydivided into two groups，with 62cases in each group.The experimental group received anesthesia induction and maintenance by Etomidate combined with Propofol （volume 1：1 mixture）. The control group received anesthesia induction and maintenance by Propofol. The HR and MAP of the two groups were recorded at each time point [before anesthesia （ T0） ，when putting the endoscope intoglotis（T），10minafterendoscope placement （T），andattheendofthesurgery（3）].Theconditions ofhypotension，hypertension，bradycardia，vasoactive drugs intervention during operation，and therecoverytime， extubation time，operation time，and the occurrence of postoperative nauseaand vomiting were compared between the two groups. Mini-mental state examination （MMSE） was used to evaluate the cognitive function of patients. Result：At T，T and T3 time points，the HR and MAP of the control group were lower than those of the experimental group （ P <0.05）.The incidence of intraoperative hypotension and the intervention rate of vasoactive drugs in the experimental group were significantly lower than those in the control group （ P <0.05）. The MMSE scores of the experimental group 3O min after extubation and1day after operation were significantly higher than those of the control group （ P <0.05）.The recovery time and extubation time of the experimental group were earlier than those of the control group （ P <0.05）.Conclusion： Total intravenous anesthesia maintenance with Etomidate combined with Propofol isused in elderlypatientswith interventionalthrapyof rigid bronchoscopy，thepatient'sintraoperative circulationismorestable，theincidenceofhypotensionissignificantlyreduced，andtheearlypostoperativecogitive impairment canbe alleviated.

[KeyWords] EtomidatePropofolTotal intravenous anesthesia Elderly patients Rigid bronchoscopy First-author'saddress：Department of Anesthesiology，theSecond Afiliated Hospital of Xiamen Medical College，Xiamen361021，China doi： 10.3969/j.issn.1674-4985.2025.21.007

硬質氣管鏡是目前治療肺部、氣道良惡性腫瘤的常用方法之一，接受治療的患者大多處于疾病終末期，且老年患者占比高，對麻醉呼吸循環(huán)的管理要求高[1-2]。（剩余5843字）