人干擾素α1b聯(lián)合布地奈德霧化吸人對腺病毒感染的下呼吸道感染患兒的影響

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[Abstract]Objective： To explore the efectof Human Interferon α1b combined with Budesonide aerosol inhalation on children with adenovirus （Adv）-infected lower respiratory tract infection （LRTI）.Method： A total of 70 children withAdv-infectedLRTIwho were treated in theSecondAfiliated HospitalofGannan Medical Universityfrom April2O24 to March2O25 were included in this study.Theywere divided into observation groupand control group by random number method， with 35 cases ineach group.Both groups were treated with LRTI routine treatment，and the control groupwas treated with Budesonide aerosol inhalation，the observation group was treated with Human Interferon ∝1b on the basis of the control group. Both groups were treated continuously for 7 days. Theinflammatoryfactors，immune functionbeforeandaftertreatment，clinical eficacy，remision timeofclinical symptoms and signs and adverse reactions were observed and compared between the two groups.Result： The clinical effective rate of the observation group was 94.29% ，which was higher than 77.14% of the control group （ P <0.05）. The relief timeofcough，pulmonaryrales，wheezingandhigh feverof theobservation group wereearlierthanthoseof the control group （ P <0.05）.After treatment， the levels of CRP，serum amyloid A， TNF -α and IL-6 in the observation group were lower than those in the control group （ P <0.05）.After treatment， the levels of CD3+，CD4 ↓+ and CD4+/CD8+ of the observation group were higher than those in the control group，while the level of CD8 ?+ was lower than that in the control group （ P <0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （ P- >0.05）. Conclusion： Human Interferon α 1b combined with Budesonide aerosol inhalation has a definite effectinthe treatmentofchildrenwithAdv-infectedLRTI，whichcanshorten therecoverytimeofchildren，improve the inflammatory response and immune function，and have a good safety.

[Keywords] Lower respiratory tract infection AdenovirusBudesonide Human Interferon α1b

First-author'saddress：DepartmentofPaediatrics，the SecondAffiliatedHospitalofGannanMedical Jniversity，Xinfeng341600，China

doi：10.3969/j.issn.1674-4985.2025.21.006

下呼吸道感染（lower respiratory tract infection，LRTI）是臨床兒科的常見病和多發(fā)病，可由腺病毒（adenovirus，Adv）、呼吸道合胞病毒、鼻病毒等多種病毒引起，Adv引起的LRTI通常較為嚴(yán)重，常發(fā)展為肺炎甚至呼吸衰竭[I-2]。（剩余7446字）