宮腔灌注粒細(xì)胞集落刺激因子用于慢性子宮內(nèi)膜炎的效果

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[Abstract]Objective：To observe the effects of uterine infusion of granulocyte colony-stimulating factor （G-CSF）on endometrial thicknes，uterine artery pulsatility index （PI） and resistance index （RI）， CD138 and/or CD38 expresion positiverate，and endometrial micropolyps in patients with chronic endometritis，and to explore itstherapeutic effcacy.Method：Patients with chronic endometritis who visited the Department of Reproductive Health Outpatientof Jiangxi Maternal and Child Health Hospital from January to June 2O22 were selected，and they wererandomly divided into two groups.The 35 patients of observation group received Human Granulocyte Colony-Stimulating Factor Injection， 150μg/d for3days，while the 35 patients of control group received oral Doxycycline Hyclate Tablets， 200mg/d for14 days.Before and after treatment， endometrial biopsies were performed under hysteroscopy for CD38 and CD138 immunohistochemical staining. Transvaginal ultrasound was used to measure endometrial thickness，uterine artery PI and RI，the therapeutic effects of the two groups were compared. Result： Compared with the control group，the thickness of the endometrium in the observation group significantlyincreasedaftertreatment，andtheuterinearteryPIandRIsignificantlyecreased，withsatistically significant differences （ P <0.05）. The expression positive rates of CD138 and/or CD38 in both groups decreased after treatment，andtherate intheobservationgroup was lower than thatinthecontrolgroup，withstatisticallysignificant differences （ P <0.05）.The incidence of small endometrial polyps in both groups improved after treatment，but there was no statistically significant difference between the two groups（ P>0.05 ）.Conclusion：Uterine infusion of G-CSF demonstrates significant clinical eficacy in the treatmentof chronic endometritis，improving endometrial thickness and blood perfusion while reducing the expression of inflammatory markers.

[Keywords] Uterine infusion Granulocyte colony-stimulating factor Chronic endometritis CD38 CD138

First-author'saddress：Department of Reproductive Health，Jiangxi Maternal and Child Health Hospital，Nanchang33oo29，hina doi： 10.3969/j.issn.1674-4985.2025.21.002

慢性子宮內(nèi)膜炎（chronicendometritis，CE）是指宮腔內(nèi)膜受感染所致的慢性炎癥反應(yīng)性疾病，臨床組織病理診斷為子宮內(nèi)膜間質(zhì)中漿細(xì)胞浸潤(rùn)，因其臨床癥狀輕微或多無(wú)癥狀，又常常被混淆為盆腔炎性疾病、陰道炎等進(jìn)行對(duì)癥處理，在臨床中常常被忽視[。（剩余8415字）