自擬安神助眠方聯(lián)合阿普唑侖片治療不寐證患者臨床療效及對睡眠監(jiān)測參數(shù)的影響

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AbstractObjective：Toexploretheclinicaleficacyofself-designedAnshen ZhumianFormulacombinedwithalprazolamtablet inthetreatmentofinsomniaanditsinfluenceonsleepmonitoringparameters.Methods：Atotalof116patientswithinsomiawho were hospitalizedinthe Departmentof NeurologybyIntegrated Chineseand Western Medicinein Qingyang SecondPeople'sHospitalfrom March2O18to March2O23wereenroledandrandomlydividedinto two groups，with58cases ineach group.Thecontrolgroup was givenO.4mg alprazolam tabletonceadaybeforeslep，nd theobservationgroup wasadditionall given Anshen ZhuanxiaFormulaonceaday，dividedintotwodoses，fortwo weeks.Ptientsinthetwogroupsof wereobservedbyastandard polysomnography，andthesleepqualityandresults fromthestandardpolysomnographyof thetwogroupswerecompared before andafterhetreatment.Results：Aftertheintervention，there werechanges insleparchitectureintheobservationgroup：thetotal sleptimesigificantlyetended，tetualsleptieigniicantlyicreased，tesleeposetlatencywasignficantlyoe， thefrequencyand durationof wakeaftersleeponset was significantlyreduced，the durationofnon-rapid eye movemensleepstage II（N3）wassignificantlyincreased，andtherapideyemovement slepstage（REM）appeared inadvance，andtheslepffciencywasimproved.ThePSQIscoreof theobservation groupwassignificantlylower thanthatofthecontrol group，withstatisticalsignificance（all P<0.05 ）. Conclusion：Self-designed Anshen Zhupian Formula combined with alprazolam tablet can effectively improve he sleep quality of patients，robust the physical functions，and enhance the mental health，etc.

KeywordsAnshen Zhumian Formula；Alprazolam tablet； Insomnia；Standard polysomnography;Clinical efect;Sleepqualityscale

中圖分類號：R338.63;R256.23 文獻(xiàn)標(biāo)識碼：A doi：10.3969/j. issn.2095-7130.2025.04.024

不寐，為臨床常見癥狀。（剩余4492字）