2</sup> 檢驗(yàn)分析顯示,睡眠障礙的發(fā)生與性別、年齡、感染途徑、婚姻狀況、文化程度、職業(yè)等因素?zé)o明顯相關(guān)性( P>0.05) ）。單因素分析結(jié)果顯示，HIV感染者睡眠障礙的發(fā)生與焦慮、抑郁、治療時(shí)間、 CD4<sup>+</sup>T 淋巴細(xì)胞計(jì)數(shù)、病毒載量、治療方案有關(guān)（ P<0.05, ），而與吸煙、飲酒因素?zé)o關(guān)( <img src="/qkimages/shsm/shsm202504/shsm20250409-1-l.jpg" with="64px" style="vertical-align: middle;"> ）。Logistic回歸分析顯示，焦慮（ OR= 3.356,95% CI為 1.465～6.782 ）、抑郁( OR=2.762,95%CI 為 1.325～5.205 ）、治療時(shí)間( OR=1.932,95%C I為 1.234～ 3.051) CD4<sup>+</sup>T 淋巴細(xì)胞計(jì)數(shù)( OR=2.192,95%CI 為 1.356～5.008 ）、治療方案( OR=1.986,95%CI 為 1.265～4.324 ）是HIV感染者睡眠障礙的主要影響因素 (0R>1,P<0.05) 。結(jié)論：HIV感染者睡眠障礙受焦慮、抑郁、治療時(shí)間、 CD4<sup>+</sup>T 淋巴細(xì)胞計(jì)數(shù)及治療方案等多因素影響，臨床需重點(diǎn)關(guān)注高危因素并給予針對(duì)性干預(yù),以改善患者睡眠狀況。-龍?jiān)雌诳W(wǎng)" />

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HIV感染者睡眠障礙的多維因素分析

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AbstractObjective：To explorethemultidimensionalfactorsofsleepdisordersinHIV-infectedindividuals.Methods：Atotalof 86HIVinfectedindividualswereincludedfrom Marchto November2O24.Demographicdataanddisease-relatedinformationof the enroled patients werecollctedandtheirsleepqualitywas evaluatedbythePitsburgh SleepQualityIndex（PSQI）.Logisticregresion wasappiedtoanalyzefactorsafectingsleedisorders inHIV-infected individuals.Results：Among the86HV-infected patients enrolled，a total of 48 patients had sleep disorders，with an incidence rate of 55.81% . The analysis chi-square test showed thattherewasnoobviouscorelationbetweentheoccurrenceof sleepdisordersandfactorssuchasgender，age，transmision route，marriage，education background，and occupation（ P>0.05 ）. The results of monofactor analysis showed that the occurrence of sleep disorders in HIV-infected individuals was related to anxiety，depression，treatment duration， CD4+ T lymphocyte count，viral load，and treatment protocol（ P<0.05 ），and not related to smoking or alcohol consumption（ P>0.05， ）. Logistic regression analysis showed that anxiety（ OR=3.356 95% CI 1.465 to 6. 782），depression（OR=2. 762， 95% CI 1.325 to 5.205），treatment duration（OR=1. 932， 95% CI 1.234 to 3. 051）， CD4+ T lymphocyte count（OR =2.192，95% CI 1.356 to 5.008），and treatment protocol（ OR=1.986，95% CI 1.265 to 4.324）were the main factors influencing sleep disorders in HIV-infected individuals （ OR>1，P<0.05 ）. Conclusion：Sleep disorders in HIV-infected individuals are influenced by various factors including anxiety， depression，treatment duration， CD4+T lymphocyte count，and treatment protocol. It is crucial to focus on high-risk factors and provide targeted interventions to improve HIV patients'sleep quality.

KeywordsHIV infection;Sleep disorders；Sleep quality；Multivariate analysis中圖分類(lèi)號(hào)：R593.3;R256.23 文獻(xiàn)標(biāo)識(shí)碼：A doi：10.3969/j. issn. 2095-7130.2025.04.009

人類(lèi)免疫缺陷病毒（Human ImmunodeficiencyVirus，HIV）主要攻擊人體免疫系統(tǒng)中最重要的CD4+T 淋巴細(xì)胞，造成免疫系統(tǒng)損害、相關(guān)免疫功能逐步喪失，從而使人體易于感染各種疾病，同時(shí)導(dǎo)致惡性腫瘤發(fā)生，最終發(fā)展成為艾滋病[1]。（剩余5279字）

目錄
monitor