重復經顱磁刺激聯合奧氮平治療在精神分裂伴失眠患者中的應用及對睡眠質量的影響

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AbstractObjective：Toanalyzetheefectsofrepetitivetranscranialstimulatiocombinedwitholanzapineothesleepqualityof patients withschizophreniaand insomnia.Methods：Atotalof ninetypatientswith schizophreniaandinsomniaadmitted to the FifthPeople'sHospitalof Zibo CityfromJanuary 2O23 to December2024were selectedastheresearchsubjects.Theywererandomly divided into a control group（ n=43 ） and an observation group（ n=47 ）by random number table. The control group was treatedwitholanzapine，whiletheobservationgroupwastreatedwithrepetitivetranscranialmagneticstimulationcombinedwith olanzapine.The Brief PsychiatricRatingScale（BPRS）wasused toevaluatethe degreeofschizophreniainbothgroupsof patients.The Pitsburgh SleepQualityIndex（PSQI）wasusedtoevaluatethechangesinsleepqualitybeforeandafterintervention， andthe incidenceofadversereactions wascomparedbetweenthetwogroups.Results：Aftertheintervention，theBPRSscoreand PSQI scoreoftheobservation groupweresignificantlylowerthan thoseof thecontrol group，andthediference betweenthe two groups was statistically significant（ P<0.05 ）； The incidence of adverse reactions in the observation group was significantly lower than that in the control group and the difference between the two groups showed no statistically significant（ P>0.05 ） . Conclusion：Thecombinationofolanzapineandrepetitivetranscranial magneticstimulationhas significanttherapeutic efectsonpatients with schizophreniaand insomia.Itisnotonlybeneficialforimprovingpatients‘mental symptoms，butalsopromotesthesleep qualtiy back to normal. It is worth promoting and applying in clinical practice.

KeywordsSchizophrenia； Insomnia；Transcranial magnetic stimulation；Repetition； Olanzapine；Mental symptoms；Sleepquality； Adverse event

中圖分類號：R749.3;R338.63 文獻標識碼：A doi：10.3969/j.issn.2095-7130.2025.04.001

精神分裂癥屬于復雜的慢性精神障礙，全球患病率約為 1% ，其核心癥狀包括陽性、陰性癥狀及認知損害。（剩余6044字）