運(yùn)動性免疫機(jī)能低下的發(fā)生機(jī)制及二氫楊梅素對其的調(diào)節(jié)作用研究

【中圖分類號】G804.32 【文獻(xiàn)標(biāo)識碼】A 【文章編號】2095-2813（2025）16-0011-04

[Abstract] In order to deal with the problem of immune dysfunction caused by high-intensity exercise，the present study systematically explored the regulatory mechanism and intervention efect of dihydromyricetin （DHM） through literatureanalysis and experimental evidence integration.The results showed that prolonged high-intensity exercise leads to an imbalance in the neuroendocrine immune network，increased secretion of immunosuppresive substances （suchas glucocorticoidsandcatecholamines），accumulationofoxygen freeradicals，anddepletionofblood glucoseand glutamine，which inturn can cause immunecell dysfunction，exacerbationof inflammatory reactions，andoxidative stress damage. DHM can improve the above situation by regulating SIRT3/HIF-1 signaling pathway to promote macrophage polarization towards anti-inflammatory phenotype; It inhibits theactivityof NLRP3 inflammatory vesicles and NF-κB signaling pathway to reduce the expression of pro-inflammatory factors; It scavenges oxygen free radicals

and enhances antioxidant capacity to improve energy metabolism.Based on this，it is recommended that athletes supplement DHM inmoderation to alleviate exercise-induced immune suppression and oxidative damage，but the safety anddose-responseofitslong-termapplicationuseofDHMstillneed tobefurther verified.The present study provides a theoretical basis for theapplicationofDHM in exercise immunomodulation，andemphasizes the needto further explore the mechanismin combination with clinical trials.

[Keywords] Dihydromyricetin; Exercise-induced immune dysfunction; Immune function; Exercise immunology

基金項目：2024年廣東省大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計劃（創(chuàng)新訓(xùn)練項目）（項目名稱：二氫楊梅素對運(yùn)動性免疫機(jī)能低下運(yùn)動員干預(yù)作用的研究，項目編號：S202413684040）;2022—2023年廣東省體育局科技創(chuàng)新和體育文化發(fā)展科研普通項目（項目名稱：不同運(yùn)動方式對肥胖兒童心血管危險因素影響的實驗研究，項目編號：GDSS2022N027）。（剩余5039字）