丁螺環(huán)酮聯(lián)合奧氮平治療老年精神分裂癥的效果分析

打開(kāi)文本圖片集

[Abstract] Objective：To explore the effect of Buspirone combined with Olanzapine in the treatment of schizophrenia in elderly.Method：A totalof 118schizophrenia in elderly patientsadmitted to theDepartment of PsychiatryofJi'anThirdPeople'sHospitalfrom June2O21to June2O23 wereselected，andthey weredivided into the observation group （Buspirone combined with Olanzapine， n=59 ）and the control group （Olanzapine， n =59） according to the treatment method.The symptoms and their severity[positive and negative symptom scale （PANSS）]， cognitive function and memory function [MoCA，Wechsler memory scale revised edition （WMS-IV）]，qualityof life and adverse reactions were compared between two groups. Result： After treatment， the scores of positive symptoms， negative symptomsand general mental symptoms in two groups were lower than those before treatment，and those in the observation group were lower than those in the control group （ P <0.05）;after treatment， the MoCAand WMS-IV scores of two groups were higher than those before treatment，and those in the observation group were higher than those in the control group （ P <0.05）;after treatment， the scores of physical function，psychological function， social function and material life state in two groups were higher than those before treatment，and those inthe observation group were higher than those in the control group （P<0.05 ）; there was no difference in the adverse reactions between two groups （ P> 0.05）.Conclusion： Buspirone combined with Olanzapine in the treatment of schizophrenia in elderly canimprove therelated negative and positive symptoms，cognitive function，memory function，improve thequalityof life，and do not increase the adverse reactions.

[Keywords] BuspironeOlanzapineSchizophrenia in elderlyMental illness First-author'saddres：DepartmentofPsychiatry，Ji'anhirdPeople'sHospital，Ji'an343ooo，China doi：10.3969/j.issn.1674-4985.2025.23.029

老年精神分裂癥是指60歲及以上首次發(fā)病或之前發(fā)病在老年期仍有癥狀或復(fù)發(fā)的情況，其病因包括大腦退行性改變、遺傳因素、軀體疾病影響（如腦血管?。┘靶睦砩鐣?huì)因素（如長(zhǎng)期孤獨(dú)、環(huán)境改變）等。（剩余5638字）