胞磷膽堿鈉聯(lián)合瑞舒伐他汀對腦小血管病認知障礙患者認知功能與運動功能的影響

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[Abstract] Objective： To investigate the effects of Citicoline Sodium combined with Rosuvastatin on cognitive function and motorfunction in patients with cognitive impairment of cerebral small vessel disease. Method：A totalof2OOpatients withcognitiveimpairmentofcerebral smallvesseldiseaseadmitedtoDepartment of Neurology，Tongliao People's Hospital from January 2O2 to January 2O24 were selected astheresearchobjects. The patients were divided into two groups by random number table method.The treatment plan forthe control group （ n ：100）wasoral Citicoline Sodium，while the observation group （n=1OO）was treated with Rosuvastatin on the basis of thecontrol group.Thecognitivefunction，motorfunction，communicationability，motionalstate，qualityoflifeand dailyliving ability were compared between the two groups.Result：Thecognitive function，qualityoflife，anddaily living abilityof theobservation group after8and12 weeks ofintervention were beterthan thoseof thecontrol group （P<0.05） .After12 weeks of intervention，the upper and lower limb motor function scores of the observation group werehigher than those ofthe control group，while the communication function scores，depresionandanxiety scores werelower than those of the control group P<0.05 ）.Conclusion：Citicoline Sodium combinedwith Rosuvastatin can improve the cognitive function of patients with cognitive impairment of cerebral smallvessel disease，which is beneficial to the improvement of motor function and the quality of life of patients.

[Keywords] Citicoline Sodium Rosuvastatin Cerebral small vessel diseaseCognitive impairment

First-author'saddress：DepartmentofNeurology，TongliaoPeople'sHospital，TongliaoO28ooo，China doi：10.3969/j.issn.1674-4985.2025.23.014

腦小血管病是因腦內(nèi)小動脈及其遠端分支、微動脈、微靜脈等小血管病變引起的一系列臨床、病理、影像綜合征。（剩余6061字）