喹硫平聯(lián)合舍曲林治療對(duì)首發(fā)青少年抑郁癥非自殺性自傷行為患者預(yù)后恢復(fù)的影響

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Effect of Quetiapine Combined with Sertraline on the Prognosis of First-episode Adolescent DepressionPatients with Non-suicidal Self-injury Behavior/ ， ， .//Medical Innovation of China，2025，22（20）： 112-115

[Abstract]Objective：To observe the effect of combined application of Quetiapine and Sertraline in the clinicaltreatmentoffirst-episodeadolescentdepresson patients with non-suicidalself-injury behavior.Method：A totalof 76 first-episode adolescent depression patients with non-suicidal self-injury behaviorwho admitted to the Third People's HospitalofChangshufromMarch 2O21 to January 2O24 were selected，andtheywere divided nto the study groupand the control groupaccording to random envelope method，with 38 cases in each group.The control group was treated with Sertraline，and the study group was treated with Quetiapine on the basis of the control group， The clinical effcacyof two groups were compared.Result：After treatment，the total clinical efective rate of the study group was higherthan thatofthecontrol group，andthe incidence of non-suicidalself-injury behavior and the scores of HAMA，HAMDand Barrattimpulsivenessscale version11（BIS-11） were lower than thoseof thecontrol group，the differences were statistically significant （ P <0.05）;there were no statistically significant differences inthe incidence of adverse reactions and treatment emergent symptom scale （TESS） score between two groups （ P* >0.05）.

Conclusion：Onthe basis of Sertraline inthe treatmentoffirst-episodeadolescentdepressionpatients with nonsuicidal self-injury behavior，combined with Quetiapinecan aleviate negative emotions，reduce non-suicidal selfinjurybehavior，withhigh practicabilityandsafety.

[Keywords] Adolescent depression Non-suicidal self-injury behavior First-episode Quetiapine

SertralineNegative emotions First-author's address： Department of Psychiatry，the Third People's Hospital of Changshu

Changshu 215500， China doi： 10.3969/j.issn.1674-4985.2025.20.026

首發(fā)青少年抑郁癥是以抑郁情緒為臨床特征的精神障礙，以顯著持久的情緒低落、精力缺乏和興趣減退等為典型癥狀，且常合并非自殺性自傷行為，即沒(méi)有自殺意圖，卻進(jìn)行不被社會(huì)認(rèn)可的、有目的性故意的、直接傷害自身的行為。（剩余5545字）