miRNAS在卵巢癌發(fā)病機(jī)制和治療耐藥中的作用

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Roleof miRNAsin the Pathogenesis and TreatmentResistance of Ovarian Cancer

WANGFang12，YANGYongxiu12.3

（1.TheFirstSchool ofClinical Medicine，Lanzhou University，Lanzhou 73OoOo，Gansu，China；

partmentofObstetricsandGynecology，theFirstHospitalofLanzhou UniversityLanzhou 73ooo，Gansu，China：

3.Gansu Province Gynecological Tumor Clinical Research Center，Lanzhou 73oooo，Gansu，China）

Abstract：Ovariancancer（OC）isthemaincauseofeathingyecologicalcancer.OCissyptomaticinthearlystageandhasnspecific symptoms in the late stage.Therefore，more than 7 5 % of OC cases are diagnosed as advanced stage.It has been reported that a variety of epigenetic fctorsch ofultipleol alsoffecteyelatedecnismathwauchsJAKSis，igaingPKigalingthay3/ATalingta InaditiontoogestsoseofOCtoandlocalofoelld thispaperintends toclarifytherelationshipbetweenmiRNAsandOC，focusingontheefectofmiRNAsonOCsignalingpathway.

Keywords：Drug resistance；Ovarian cancer；Pathogenesis；MicroRNA

卵巢癌是全球第三大最常見的婦科惡性腫瘤腫瘤由多種組織病理學(xué)實體組成，卵巢癌的最常見的組織學(xué)類型包括：漿液性卵巢癌、子宮內(nèi)膜樣卵巢癌、粘液性卵巢癌、透明細(xì)胞卵巢癌。（剩余14516字）