PI3K/Akt信號通路在中醫(yī)藥靶向骨關節(jié)炎中的應用研究

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Applicationof PI3K/Akt Signaling Pathway in Traditional Chinese Medicine Targeting Osteoarthritis

ZHANGDeyu1，PANShengqiang1，LINing2

（1.Clinical CollegeofTraditional ChineseMedicine，Gansu UniversityofTraditional Chinese Medicine，

Lanzhou 73000o， Gansu， China；

2.DepartmentofOrtopedicsndTaumatologyintaoHospitalofaditionalCineseedicin，LintaoO，GsuCina） Abstractarilodtoalreatofadearireisetieat ClinicalndexperimealstudieshavefoundthattraditialCinesemedicinecaniterfewitheourrencendprogressiofAby participatinginhAtsialigthecifnslatedatioofecartililsi andfunctionalracteritofhodrocsbctiatigteifaatorysposeioedinktigalingtatede jointuiuevaadeadeohtldegessefoet signalingpatrovidesargetsndeasfradiioalCineseedcintteveeiOutearlativelylatedasd systematidiscusiosereforesedth3K/AtsigalingathathesearchulsftaditoalCneseicieod compoundpresitosotisatyinecetearsreoredutindertprovideeoreticalbasisforliicalprevetiondtrat of OA.

KeyWords：Osteoarthritis；PI3K/Akt signalingpathway；Traditional Chinese medicine

骨關節(jié)炎（osteoarthritis，OA）本質(zhì)上是一種退行性疾病，現(xiàn)代醫(yī)學認為OA病因主要涉及滑膜組織炎癥變化、不平衡的氧化應激和調(diào)節(jié)軟骨合成代謝和分解代謝的基因的異常表達，這些基因可能是由年齡、肥胖、炎癥、創(chuàng)傷和遺傳因素等多種潛在危險引起或加劇[12]。（剩余14989字）