特發(fā)性肌炎相關(guān)肺間質(zhì)病與特發(fā)性肺纖維化的 臨床比較
打開文本圖片集
Clinical Comparison Between Idiopathic Myositis-associated Interstitial Lung DiseaseandIdiopathicPulmonaryFibrosis
ZHANGMing1，2，ZHOUShuhong3，ZHANGKait，CHENYing3，LIANGLiuna3，ZHANGZhaocui3，PANLiang （1.TheFirstClinicalMedical CollegeofGansu Universityof Chinese Medicine，Lanzhou 73oooo，Gansu，China； 2.DepartmentofImmunorheumatology，ZhangyeSecond People'sHospital，Zhangye7340o，Gansu，China； 3.Department of Immunorheumatology，Gansu Provincial Hospital，Lanzhou 73oooo，Gansu， China； 4.DepartmentofGeriatrics，Shaanxi Second ProvincialPeople's Hospital，Xi'an7o，Shaani，China）
Abstract：Obeiarealcestasitsdo pulmonaryfibrosis（F）.MethodsAtotalof43patientsdagnosedwithDDoerehospitaledinourospitalfroOctobe1o October2021wreselecedAccodingtoeresultsfDA5ntbodytestterddintoDA-Dop（13）ndD group（n=30）Iditio，OpatitsiheospitalizdringteseidreseleedsFoup.Tegeneadiio lnicaymptoatoaiorctodftosseielalds ofdiseaseinDA-DopassortertanthatinoDA-DoupdIouplaniemiotrasferaseandGCOsorsrer thanthosinIopighsilooteiaslerantatinopaineaiotrasferasndOoesheraoe in non-MDA5-ILD group（ P < 0 . 0 1 6 ） .The positive rate of ARSantibody innon-MDA5-ILD group washigher than that in MDA5-ILD group（ P < 0.016）.Thepositive rateof muscleenzyme elevation in IPFgroup was higher than that in MDA5-ILD group（ P<0 . 0 1 6 ） .Male patients，age of onset， （20 D L C O % prereduction，F(xiàn)scoreand Cscore inIPFgroup were higherthanthose in MDA5-ILDgroupandnon-MDA5-ILD group（ P<0 . 0 1 6 . Thelung functionoftosodsrielaouciiouoTCaifciofDos morecommonwithAIPandOP.TheHRCTclassficationofthenon-MDA5-ILDgroupwasmorecommonwithNSIPConclusionTheclinical characeristicsofeompeelyentfrooofourereiecicalacteris and non-MDA5-ILD.Myositis antibody and HRCTplayan important roleinthe diagnosis and treatmentof ILD.
Key Words：Interstitial lung disease； Idiopathic myositis； Idiopathic pulmonary fibrosis；MDA5antibody
多發(fā)性肌炎（polymyositis，PM）和皮肌炎（der-matomyositis，DM）是一組以骨骼肌的免疫炎癥為主的自身免疫性疾病，為特發(fā)性肌炎（Idiopathic in-flammatorymyopathies，IMs）中最常見的兩種類型，可累及皮膚、肺臟、關(guān)節(jié)等全身器官；累及肺臟出現(xiàn)間質(zhì)性肺疾?。╥nterstitial lung disease，ILD）是導(dǎo)致患者死亡最重要因素。（剩余9020字）