基于孟德爾隨機(jī)化分析探討骨關(guān)節(jié)炎與2型糖尿病的關(guān)聯(lián)

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AssociationBetween Osteoarthritisand Type2DiabetesMellitus Based on Mendelian Randomization Analysis

MALixin1，XUZujian12

（1.CollegeofItegrativeineseandWesternMedicine，outhwestedicalUniversity，Luzou646oo，ichuanCina；

.DepartmentofropdsdJots，latedspialoditoalseiceouwestcalUih

，Sichuan， China）

Abstract：Oel associationstudy（GW）sumarydatafrodfrenteseachinstutiossuchsrcOGENUKiobank）wersedOusedssure factorandTDMwasusedasanutcomevariableMultileMendelianrandomzation（M）analysisetods，includingversevariaceeihtin （VW）weida TDMrisk.ResultshrsusofIVWowdatOAsociatedigsofD（OR9%Co0O valueofMR-Egdosisttiatfgeegessodattsaedidottal polytropy .Cochrane'sQ test showed no heterogeneity in IVs .Sensitivity analysis showed that the causal effect was stable. Conclusion MR analysis support that OA is associated with an increased risk of T2DM.

Key Words：Osteoarthritis；Type2 diabetes melitus； Mendelian randomization； Genome-wide association study

骨關(guān)節(jié)炎（osteoarthritis，OA）是一種好發(fā)于老年群體的關(guān)節(jié)退行性疾病，其發(fā)病與多因素相關(guān)，如年齡、體重、炎性因子、創(chuàng)傷及遺傳等，常累及肩、脊柱、髖、膝等關(guān)節(jié)部位。（剩余8594字）