基于網(wǎng)絡(luò)藥理學(xué)探討黃芩治療肺癌的有效成分和作用機制

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Abstract：ObjeciveToanalyethepotentialtargetsandmechansmofadixsuteliaeinthetreatmentoflungcancerbasedoetwork pharacologetodshecieomponntsndargegnesofdiutellieerebandPndeungnced wereobtainedyeCardndOaabasndeintersectioeesofttoeretakenTePetwkdagaofttio geneswasobtaiedusingteStringdatabaseandthGOanalysisndKEGGerichmentanalysisoftekeyargetgeneswereperfodusingthe R （2 softwareustelcagsultsotalofouds4opodgetsd4ngceadetd Therewere55odesnd8eodesinproteininteractionetworkGOfucioalrichentaalysisaied93ologicalprod KEGGpathwayeichentaalysisbained37igalingpathwayseainactivecomponentssuchsogoninicaleincacetind β 1 siosteroleredededUGAKa mainlyncludeEosallellgedialisiis radix scutellariae，such as wogonin，baicalein，acacetin and β -sitosterol，mayact onAKT1，IL6，HIF1A，JUN，CCND1，ESR1，PTGS2，VEGFAand othertargetstougAGERAGE，I7poptosisallcellungancer5ndhersigaigpathwandnplaeolefd scutellariae inanti-lung cancer，showing thecharacteristicsof multi-component，multi-targetand multi-pathway.

KeyWords：Network pharmacology；Radix scutellariae；Lung cancer；Active component

肺癌（lungcancer）作為全球范圍內(nèi)發(fā)病率和致死率均居于首位的惡性腫瘤類型，其的疾病負(fù)擔(dān)在臨床腫瘤學(xué)領(lǐng)域備受關(guān)注，從全球癌癥流行病學(xué)分布特征分析，肺癌呈現(xiàn)出顯著的疾病負(fù)擔(dān)二元性特征[1。（剩余11085字）