甲基蓮心堿對(duì)糖尿病腎病大鼠腎臟氧化應(yīng)激的影響

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Effectof Neferine on Oxidative Stressin Kidney ofDiabeticNephropathy Rats

HUANGHongmei1，LI Tingl，LIYingl，YUANLul，GUShi'，XUYong2 （1.DepartmentofEndocrinology，theFirstPeople'sHospitalofSuangliuDistrict，Chengdu6O2Oo，Sichuan，hina；

2.DepartmentofEndocrinology，AfiliatedHospitalofSouthwestMedicalUniversity，Luzhou646o99，Sichuan，China）

Abstract：OjectiveToivestigatethefectofeferineenaloidativetressinatsitabeticphropatyMetdSDaleatse randomlydividedintootrolgouodeloupaetoupdosiiecotrolgouIditiotootrolouthou werfedwithigsurndigfatdettoakeDodelAftersucfulodelingroupeddrugtreatentTeontrogroundedel groupwereitragastricallyadministeredwiththesameamountofsaline，thetreatment groupwasintragastricallyadministeredwith 4 0 m g / k g neferine， and the positive control group was intragastrically administered with 1 4 m g / k g irbesartan.HE staining was used to observe the pathological conditions ofratkidneytisederticalmcroopeoecalalsisofuiaryrotenontiatsasefodEassedtete contents of TNF- ，SODandMDAinratkidneytissue.ResultsComparedwiththecontrol group，therenaltisue structureof themodel groupwas signficantldteotldttaltldd contents of MDA and TNF- were significantly increased（ .Compared with the model group，the local renal tissue of the treatment group was damaged to varying degrees，the urine protein of the treatment group was significantly reduced （ P<0 . 0 1 ） ，the content of SOD was increased（ P<0 . 0 5 ） ， and the content of MDA and TNF- was decreased in the treatment group （ .Conclusion Neferine can improve the damage of renal tissue in diabetiephoatetoedeaieaspeio of diabetic nephropathy rats.

Keywords：Neferine；Diabetic nephropathy；Oxidative stress

糖尿病腎?。╠iabeticnephropathy，DN）是終末期腎衰竭的主要原因[，隨著時(shí)代發(fā)展，DN的發(fā)病率也在不斷增高，已經(jīng)成為當(dāng)前最重要的公共衛(wèi)生問(wèn)題之一[2。（剩余6069字）