允許性高碳酸血癥對(duì)腹腔鏡手術(shù)老年患者術(shù)后認(rèn)知功能的影響及研究進(jìn)展
Impact and Research Progress of Permissible Hypercapnia on Postoperative Cognitive Dysfunctiol in Elderly Patients Undergoing Laparoscopic Surgery/MIN Xue， LYU Zhijian， LI Kongbing， JIA Yujie WANG Dongmei. //Medical Innovation of China， 2025， 22（10）： 183-188
基金項(xiàng)目：青海大學(xué)附屬醫(yī)院（臨床醫(yī)學(xué)院）科學(xué)創(chuàng)新基金項(xiàng)目（FYXC-2024-06）
通信作者：呂志堅(jiān)
[Abstract]In current medical practice， with the extensive application of laparoscopic technology in elderly patients， postoperative cognitive dysfunction （POCD）has become a key problem affecting the rehabilitation and quality of life of elderly patients. Permissible hypercapnia （PHC）is an acceptable respiratory acidosis resulting from theuse of low tidalvolume protective ventilationstrategies.Clinical studieshave shownthat theapplication of PHC in laparoscopic surgery can improve postoperative cognitive function in elderly patients through various mechanisms.It is important to note that although PHChas shown potential benefits in multiple studies， several key issues regarding its use inelderly patients remainunclear：first， the mechanismof overall effect of PHC on the physiological status ofelderly patients hasnot been fully elucidated； secondly，the specificrole of PHC strategy in postoperativepain managementand itspotentialimpact onpostoperativecognitive function stillneed tobe further verified；finally，thereis stillalackofclear clinicalconsensus onkeyparameterssuchasallowablelimitsandsafe limits for CO during PHC therapy. In this paper， we reviewed the influence of PHC ventilation strategy on elderly patients undergoing laparoscopic surgery and the related mechanisms.
[Key words] Permissible hypercapnia Postoperative cognitive dysfunction Laparoscopic surgery Elderly patients
First-author's address： Surgical Anesthesia Center， Afliated Hospital of Qinghai University， Xining 810001， China
doi：10.3969/j.issn.1674-4985.2025.10.043
術(shù)后認(rèn)知功能障礙（POCD）是術(shù)后常見(jiàn)的并發(fā)癥之一，在老年患者中尤其普遍。（剩余11079字）