火針聯(lián)合沙利度胺對(duì)結(jié)節(jié)性癢疹患者皮損情況及生活質(zhì)量的影響

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Effect of Fire Needle Combined with Thalidomide on Skin Lesions and Quality of Life of Patients wit Prurigo Nodularis/LIU Hongchun， ZENG Chaoqin， XIONG Ying. //Medical Innovation of China， 202： 22（10）： 097-101

[Abstract]Objective：To investigate theeffct of fire needle combined with Thalidomide on skinlesions and quality of life of patients with prurigo nodularis （PN）.Method： A total of 80PN patients admitted to the Department of Dermatology，F(xiàn)engcheng Third People's Hospital from January 2023 to May 2024 were selected and divided into control group and treatment group according to random number table method， with 40 cases in each group.The control grouptook Thalidomide Tablets orally，andthe treatment group was treated with fire needle onthe basis of the control group. The skin lesions， serum biochemical factors [tumor necrosis factor （TNF）- α ，substance P （SP） and interleukin （IL）-6]，qualityof life[dermatology lifequality index（DLQI）]and mental and psychological state [Beck anxiety inventory （BAl）Beckdepresson inventory （BDI），Pitburgh sleepqualityindex （PSQI）and perceived stress scale（PSS）scores]beforeandafter treatment，andclinicalefficacyandthe incidenceofadversereactionsof the two groups were compared. Result： There were no significant differences in skin lesions，serum biochemical factor levels，quality of lifeand mental andpsychological statebetween the two groups before treatment （ P >0.05）. After treatment，compared with control group，skinlesions scores，the scores of DLQI， BAI，BDI， PSQI， PSS， andthe levels of TNF- α ，SP and IL-6 in the treatment group were significantly lower，the clinical total effective rate was significantly higher， the differences were statistically significant （P<0.05） . There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05 . Conclusion： The effect of fire needle combined with Thalidomide on PNis outstanding， and the skin lesions，serum biochemicalfactors， quality of life and mental and psychological state of patients are significantly improved， and the safety is good.

[Key words] Fire needle Thalidomide Prurigo nodularis Skin lesions Quality of life

First-author's address： Department of Dermatology， Fengcheng Third People's Hospital， Fengcheng 31100， China

doi：10.3969/j.issn.1674-4985.2025.10.023

結(jié)節(jié)性癢疹（PN）屬于慢性瘙癢性皮膚病，以丘疹和結(jié)節(jié)為主要臨床表現(xiàn)，伴有頑固性的劇烈瘙癢，多分布于四肢伸側(cè)，治療較為困難，嚴(yán)重影響患者的生活質(zhì)量，其發(fā)病機(jī)制復(fù)雜，可能與免疫細(xì)胞、神經(jīng)因素、汗腺功能及心理因素等有關(guān)。（剩余6203字）