可樂定透皮貼片聯(lián)合硫必利治療兒童抽動障礙的療效分析

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Therapeutic Effect of Clonidine Transdermal Patches Combined with Tiapride in the Treatment of Tic Disorders in Children/LIAO Wenjuan， LUO Juanjuan， ZHU Huifang， CHEN Hengwei， ZENG Wenhui， GUO Bangming.//Medical Innovation of China， 2025， 22（10）： 010-013

[Abstract]Objective：To explore the effcacy of Clonidine Transdermal Patches combined with Tiapride in thetreatmentofchildren withticdisorder.Method：Atotalof106childrenwith ticdisorder admittedtothe First AffliatedHospitalof GannanMedical Universityfrom January 2023toJanuary 2024 were selectedanddivided into two groups with 53 cases in each group according to random number table method.Thecontrol group was treated with Clonidine Transdermal Patches and the observation group was treated with Clonidine Transdermal Patches combined with Tiapride.Theclinicaleffcacy，drug onset time， disease control time and adverse reactions were compared between thetwo groups.The severityof ticdisorder was also assessed before treatment andafter 2，4，6， and8 weeks of treatment.Result： Compared with the control group，the drug onsettime inthe observation group was earlier， the disease control time was shorter， and the total effective rate was higher （ P <0.05）.After 2， 4，6 and 8 weeks of treatmenttheseverityscoresofticdisorder intheobservation groupwerelowerthanthose inthecontrol group （ P <0.05）.There was no significant difference in the incidence of adverse reactions between the two groups ）.Conclusion： Thetreatment of tic disorders in children with ClonidineTransdermal Patches combined with Tiapridehas significant efficacy， which can reduce the severity oftic disorders， alleviate symptoms，and promote

基金項目：贛州市科技計劃項目（20222ZDX8578）

贛南醫(yī)科大學第一附屬醫(yī)院兒科江西贛州341000 贛南醫(yī)科大學第一附屬醫(yī)院神經外科江西贛州 341000通信作者：郭邦明

physical recovery， and the safety of single treatment and combination therapy is comparable.

[Key words] Clonidine Transdermal Patches Tiapride Tic disorde]

First-author's address： Department of Pediatrics， the First Affiliated Hospital of Gannan Medical University， Ganzhou 341000， China

doi：10.3969/j.issn.1674-4985.2025.10.003

兒童抽動障礙通常是指以突發(fā)、重復、不自主抽動為特征的一種精神障礙性疾病，常見于兒童-2]。（剩余5991字）