VEGF相關(guān)機(jī)制在結(jié)直腸癌中的研究進(jìn)展

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Research Progress on VEGF Related Mechanisms in Colorectal Cancer/QIN Guan， HUANG Zansong. //， 2025， 22（10）： 178-183

[Abstract]Colorectal cancer （CRC）is one the malignant tumors with high incidence rate and mortality worldwide.Its complexity and high metastasis have brought great challenges to treatment.Vascular endothelial growth factor （VEGF），asone the most important factors stimulating angiogenesis， plays acrucialrole in the occurrence， development， metastasis， and prognosis CRC. This article reviews the biological characteristics VEGF and its mechanism action in CRC， including promoting tumor angiogenesis， regulating the tumor microenvironment，and mediating tumor invasion and metastasis.In addition，this article also explorestreatment

① 右江民族醫(yī)學(xué)院研究生學(xué)院廣西百色533000

② 河池市第一人民醫(yī)院消化內(nèi)科廣西河池546313

③ 右江民族醫(yī)學(xué)院附屬醫(yī)院消化內(nèi)科廣西百色 533000 通信作者：黃贊松

strategies targeting VEGF and its related pathways， such as Bevacizumab， Tanshinone IIA， chemotherapy combination， programmed cell death protein 1（PD-1）/VEGF bispecific antibodies， and multi-target kinase inhibitors.These treatment strategies have shown good eficacy in the treatment CRC， but further research and optimization are still needed.

[Key words] Colorectal cancer Vascular endothelial growth factor Related mechanisms Treatment strategy

First-author's address： Graduate College Youjiang College for Nationalities， Baise 533000.

doi：10.3969/j.issn.1674-4985.2025.10.042

結(jié)直腸癌（colorectalcancer，CRC）是全球范圍內(nèi)發(fā)病率和死亡率均較高的惡性腫瘤之一，尤其在我國的發(fā)病率逐年上升，已成為僅次于肺癌和胃癌的全球第三大最致命的癌癥。（剩余10320字）