黃芪活性成分調(diào)控NLRP3炎癥小體延緩糖尿病腎病機制

[Abstract]Diabeticnephropathy（DN）isoneof the most prevalent microvascular complications ofdiabetes melitus （DM）， characterizedbyprogesivenaldfuntionultiatelyeadingtondstagerenaldisease.Th“inflmmatorysponse-fbos”ais playsacicaloleinteprogessonof，withteNOD-likeeceptorthalproteinomai-assiatedprotein3la masomerecogedasakydivroftisprocess.Understandingteinterplaybetweeniflmationrosis，ndNflsomeactivatioisessntialfordevelopingefectivestrategiesforDpreventionandtreatmentAtragalusmembranaceusisawidely usedtraditioalChinesemedicineinDNmanagement，anditsactivecomponentshavebenshowntointerferewithNRP3inflammsomeinititonandactivatonterebymitigatingDprogresion.TiseviewhglightsthepivotaloleofteNRP3inflmsoein the“inflammatoryresponse-fibrosis”mechanismofNandexploresthetherapeuticpotentialofAstragalus membranaceusinargeting NLRP3inflammasomeactivityBysummarizingcurentevidence，thisarticleaims toprovidenewinsightsintotargetedtherapetic strategies for DN.

[KeyWords]Astragalus memeranaceus；Activecomponent；NOD-likereceptorthermal proteindomainassciated protein3; Diabetic nephropathy；Renal interstitial fibrosis；Inflammatory

糖尿病腎?。―iabeticnephropathy，DN）是糖尿病最主要的微血管并發(fā)癥之一，以腎小球硬化、腎間質(zhì)纖維化（Renalinterstitial fibrosis，RIF）為結(jié)局，走向終末期腎病。（剩余11648字）