疏肝健脾法治療腹瀉型腸易激綜合征作用機(jī)制研究進(jìn)展

【中圖分類號】R256.34 【文獻(xiàn)標(biāo)志碼】A 【文章編號】1007－8517（2025）11-0072-04

DOI：10.3969/j. issn.1007-8517.2025.11. zgmzmjyyz202511015

ResearchProgressontheTherapeuticMechanismsofLiver-Soothingand Spleen-Strengthening Therapy forDiarrhea-Predominant Irritable Bowel Syndrome

KANG Hongchang1，2WANG Chunyan1，2LI Mingyue1，2JI Jianbin1.2 1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 3Oo38O，China; 2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，Tianjin 30o380，China

Abstract：Diarrea-predominant iritablebowel syndrome（IBS-D）isoneof themostcommonfunctionalbowel disordersand hasdrawsignificantiicalatention.LiverdepressionndspleedeficiecyareecoizedasthefundamenalpathogesisofI D，andtheclinicalaplicationofliver-sothingandspleetrengtheningthrapyhasdemonstratedconsiderablepotentialode research indicatesthatthis therapeuticappoach mayexert itsefectsthrough multiple mechanisms，including：regulating brai-gut peptide expresio，ducngvisralhesesitivity，lvatigintestialifamatosposs，gatingsyolocalacto， modulatingguticoiota，epiingitestialmucosalaiers，andiproinggastrotestialotlitdsods.isvt sizescurrentresearchliteratureonthemechanisticbasisof lver-sothingandspleen-strengtheningtherapyforIBS-D，aimingto provide references for both clinical practice and scientific investigation.

KeyWords：Liver-Soothingand Spleen-Strengthening Therapy；Diarhea-Predominant Iritable Bowel Syndrome（IBSD）；Mechanism of Action；Experimental Research；Review

腸易激綜合征（irritablebowel syndrome，IBS）作為臨床常見的功能性腸病之一，以腹痛、腹瀉或便秘為主要臨床表現(xiàn)，且尚未發(fā)現(xiàn)器質(zhì)性疾病可以解釋上述癥狀[1]。（剩余8527字）