阿膠和阿膠肽對血管內(nèi)皮細胞氧化損傷的作用研究
打開文本圖片集
關鍵詞阿膠；阿膠肽；過氧化氫；人臍靜脈內(nèi)皮細胞；氧化損傷
中圖分類號R285文獻標識碼A
文章編號 0517-6611（2025）08-0162-06
doi：10.3969/j.issn.0517-6611.2025.08.035
開放科學（資源服務）標識碼（OSID）：
Abstractbective]Toaalyeteoleoforiollini（Ejia）adEjpeptideinoxidatiestressijuyofscularedothelialcels andthemechanismoftheirrole.[Metod]Themodelofhumanumbilicalveinendothelialcellinjuryinducedbyhydrogenperoxide（ ） wasestablishedTetsofEjaodEjapeptideontesurvialateofumanmblcalvendothelialcs（HUVEC）beforeadfter modelingweredteedbyCCK-8eeectsofEjandEjaopeptideonthactitiesofcellsuperoxidedsmutase（SOD）glutatioepe oxidase（GSH-px），lactatedehydrogenase（LDH）andtecontentsofalondialdehde（MDA）ascuarendthelialgrowthfctor（EGF）， interleuki-6（-6）ricide（NO）reded.esultEdEpeptidouldectivelyproteeproliferatiodo of HUVEC，and could effectively resist the proliferation inhibition caused by oxidative injury. Ejiao and Ejiao peptide could significantly inhibit the excessive production of MDA and LDH， Ejiao could significantly increase the enzyme activity of GSH-px，Ejiao peptidecouldsignificantlyincreasetheexpressonlvelofSODandrepirteoidativeijuyofHUVCBothEjiaoadEjapeptideould effectivelyproefyulardolpottsdelalfucioteeoVGy vascularendoelialelluceotf6ooteogsisduceatoactoocisf EjiaoandEjioeptideducinoidativestressofECabelatedtprovingcellgrowhndproliferatiohncingeltioidantenzymeactivityrotigtexpresiofsredoelialgowthfctorandprootigtesetioofbasadelal cells.
Key wordsCorii colla asini（Ejiao） ；Ejiao peptide；Hydrogen peroxide ）； Human umbilical vein endothelial cells（HUVEC） ；Oxida-tive injury
由于當今世界的人口日益老齡，許多慢性疾病如冠狀動脈粥樣硬化、糖尿病和脂肪肝的患病比例正在不斷上升[1]與高血壓、高血脂、衰老等疾病密切相關的血管內(nèi)皮細胞功能的損傷研究逐漸引起人們的重視[2]。（剩余10719字）