轉(zhuǎn)運RNA衍生小RNA（tsRNA）的生物學(xué)功能及在肝臟疾病中的表達(dá)和臨床意義

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基金項目：國家自然科學(xué)基金（81804142，82474570）；中國博士后科學(xué)基金面上項目（2023M731027）

Abstract：Liverdiseases cannot beeasilydetected in theearlystage，andalthough invasivediagnostic methods，suchas liver biopsy，arerelativelyaccuateteytendtoavealowdegreofacceptane，ichgreatlyliitstheimprovementindagnosisand treatmenttechiquesforliverdiseases.ThereforeitisofgreatimportancetosearchfornewiomarkersandtherapeuticagetsAsan emerging biomarkerforliquidbiopsy，tNA-derivedsmallRNA（tsNA）isbnomallexpressedinvarious liverdiseasesincluding viralhepatitisfattlveease，lveriuryndlraentvelodprogessflissby regulatingthebiologicalfunctionssuchasgeneexpresion，epigeneticregulation，andproteintranslation.Thisarticlereviewsthe origin，clasification，andbiologicalfunctionoftsRNA，aswellastheresearchadvancesintRNAasbiomarkersandpotential therapeutic targets forliverdiseases，soas to provideideas fortheearlydiagnosisand treatmentof liverdiseases.

KeyWords：MicroRNAs;LiverDiseases;Biomarkers

Research funding：National Natural ScienceFoundationof China（81804142，82474570）；ChinaPostdoctoralScienceFoundation General Program（2023M731027）

世界衛(wèi)生組織報告顯示，肝病相關(guān)死亡率存在顯著地域差異：亞太地區(qū)肝病致死占比達(dá) 4.6% ，顯著高于美洲 （2.7% 和歐洲地區(qū)（ 2.1% ）[1]。（剩余19018字）