表觀遺傳學(xué)在瘦型非酒精性脂肪性肝病中的作用及臨床應(yīng)用前景

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關(guān)鍵詞：非酒精性脂肪性肝??；表觀基因組學(xué)；病理過程

基金項(xiàng)目：國家自然科學(xué)基金（81904154，82205086）；河南省科技攻關(guān)計(jì)劃（242102310500）；河南省“雙一流”創(chuàng)建學(xué)科中醫(yī)學(xué)科學(xué)研究專項(xiàng)（HSRP-DFCTCM-2023-1-10）

Abstract：Epigeneticmechanismsplayacrucialroleinthedevelopmentandprogresionof nonalcoholicfaty liverdisease （NAFLD），especiallamong lean individuals.Theresearchonrelated epigenetic mechanismshasprovidednewcluesand direction forrevealing theunderlyingcausesandtreatmentstrategiesofNAFLD.Thisarticleintroduces theroleofepigeneticsin thedevelopmentandprogresioofNAFLDamongleanindividualsinrecentyears，analyzesthelatestresearchadvances inthe epigeneticsofNAFLDinthispopulation，and brieflydescribesthebasicconceptsofepigenetics，includingDNAmethylation， histonemodifications，andnon-codingRNAregulation.Thisarticlealsodiscusseshowepigeneticalterationsimpactthe pathogenesis，disease progression，and treatment strategies of NAFLD in lean individuals.

KeyWords：Non-alcoholic FattyLiver Disease；Epigenomics；Pathologic Processes

Researchfunding：NationalNatural ScienceFoundationof China（81904154，82205086）；ScienceandTechnology KeyProject of Henan Province（242102310500）；Special ResearchProjectfor Traditional Chinese Medicine Sciencein Henan Province's “Double First Class” Creation Discipline（HSRP-DFCTCM-2023-1-10）

非酒精性脂肪性肝?。∟AFLD）包括非酒精性單純性肝脂肪變、非酒精性脂肪性肝炎（NASH）肝硬化和肝細(xì)胞癌（HCC）[I]，是指排除酒精等明顯造成肝損傷的因素之外的一種多系統(tǒng)代謝性疾病[2]。（剩余16491字）