慢加急性肝衰竭預(yù)后評分模型和標(biāo)志物研究進(jìn)展
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Research advances in prognostic score models and biomarkers for acute-on-chronic liver failure
XU Xinyi，YU Xia，TUHuilan，QIAN Xiaohan，YANGYida，SHI Yu
StateKeyLboatorfogosisndTrmentffectioeas，estfatedHospitalejngUesityoolof
Medicine.Hangzhou310003，China
Corresponding author： SHI Yu， zjushiyu@zju.edu.cn （ORCID： 0000-0002-9392-7176）
Abstract：Acute-on-chronic liverfailure（ACLF）isacomplexclinicalsyndrome，andearlyidentificationandaccurateprognostic evaluationareof greatimportanceforpatienttreatmentandmanagement.Inrecentyears，within-depth researchonthe pathogenesisofACLF，multipleprognosticbiomarkershaveeenproposedandusediclinicalpractice.Thisarticlesysteatialy reviews theresearchadvances inprognosticbiomarkersforACLFfromtheaspectsof clinical predictive models，immunological biomarkers，metabolic biomarkers，geneticandepigenetic biomarkers，microbiome-related biomarkers，andemerging technologies suchasartificialintellgenceandulti-omics，nditalsodiscusestevalueandapplicationprospectsoftesebiomarkesthe prognostic evaluationofACLFandproposesfutureresearchdirections，norder toprovideasientificandcomprehensivereferencefor clinicians，guide individualizedtreatmentandmanagementofACLFpatients，ndfinallimprovetheclinicaloutcomesofatients.
Key Words：Acute-On-Chronic Liver Failure;Prognosis；Biomarkers；Models，Statistical
Research funding： National Key Research and Development Program of China （2O22YFC2304500）
慢加急性肝衰竭（ACLF）是一種慢性肝病急性加重引起的危重癥，常伴發(fā)多器官功能障礙，其病死率極高。（剩余21970字）