代謝組學(xué)在中醫(yī)藥防治肝衰竭中的應(yīng)用進(jìn)展

基金項(xiàng)目：國家自然科學(xué)基金（82360912，81960841，82274434）；廣西自然科學(xué)基金（2023GXNSFBA026190）；廣西中醫(yī)藥大學(xué)博士科研啟動基金（2021BS028）；廣西高校中青年教師科研基礎(chǔ)能力提升項(xiàng)目（2022KY0299）；廣西中醫(yī)藥大學(xué)第一附屬醫(yī)院科研項(xiàng)目（2021QN004）

Abstract：With theconcurrent developmentof traditional Chinesemedicine（TCM）and metabolomicsinthediagnosisand treatmentof iverfailure，techniquessuchasnuclear magneticresonance，massspectrometry，chromatography，metabolic flux analysis，andbioinformaticsenablethequalitativeorquantitativeanalysisofndogenoussmallmoleculemetabolitesinanimal modelsof liverfailureandpatientswithliverfailure.These methods helpidentifyspecificbiomarkersforearlydiagnosisand clinicalintervention.Thisarticlereviewsrecentdvancementsinmetabolomicsforthearlydiagnosisofliverfailure，biomarker discovery，identificationofTCMsyndromes，andtheapplicationofTCMintreatingliverfailure，aimingtoprovideabasisforCMbased diagnosis and treatment of liver failure.

Key words：Liver Failure；Metabolomics；Biomarkers；Traditional Chinese Medicine Therapy

Research funding：National NaturalScienceFoundationof China （82360912，81960841，82274434）；Guangxi Natural Science Foundation（2O23GXNSFBAO26190）；Guangxi UniversityofTraditional ChineseMedicineDoctoralResearchFoundation（202BS28）； Guangxi UniversityofTraditionalChinese MedicineYoung Teachers’ScientificResearchFoundationAbilityImprovementProject （2022KY0299）；TheFirstAfiliated HospitalofGuangxi Universityof Traditional Chinese Medicine ScientificResearch Project （2021QN004）

肝衰竭病死率高，嚴(yán)重威脅人類健康。（剩余17156字）