原發(fā)性膽汁性膽管炎合并干燥綜合征的免疫機制及靶向治療研究進展

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Abstract：Primary biliarycholangitis（PBC）and Sjogren’ssyndrome（SS）are bothautoimmune disorders characterized by the involvementofepithelialtisse，andcomorbidityofPBCand SSisoftenobservedinclinicalpractice，suggesting thatthesetwo diseasesmayhavecommon pathogeneses.Currently，thereare stillnospecifictargeted therapies forPBCand SS，and the therapeuticapproach forsystemic manifestations mainlyrelieson the treatmentregimens forotherautoimmunedisorders.This articlereviewsthevarious potentialtherapeutictargets thathavebenclarifiedinthepathogenesisofPBCandSSandpointsout thattargeted therapies forthesetwodiseasescanbedevelopedbasedonthecommon immunopathologicalmechanismof PBCand SS，thereby providing valuable ideas for developing novel therapies.

Key words： Primary Biliary Cholangitis； Sjogren’s Syndrome; Immunomodulation； Molecular Targeted Therapy tesearch funding：Natural Science Foundation Project of Liaoning Province（2O23-MS-189

原發(fā)性膽汁性膽管炎（primarybiliarycholangitis，PBC）和干燥綜合征（Sjogren'ssyndrome，SS）均在中老年女性中多見[1-2]，兩者發(fā)病時均以疲勞、乏力和瘙癢癥狀常見。（剩余21218字）