胰島素樣生長因子-I（IGF-I）在肝硬化預(yù)后評估和治療中的作用

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Abstract：Asakeymemberof theinsulin-likegrowthfactorfamily，nsulin-likegrowthfactor-I（IGF-I）ismainlysythsized intheliverandiswidelydistributedinthehumanbody，anditisivoledintephysiologicalproessssuchscellprolifation， diferentiation，metabolism，andapoptosis.StudieshaveshowtatthelevelofIGF-Iisnegativelycorelatedwiththeseverityof livercirrhosis，andIGF-Imainlyafectstheprogressionoflivercirrhosisbyinibiting liverfibrosis，promotingDNAdamage repair，andregulatinglipid metabolism.MonitoringofIGF-Ilevelisexpected toprovideanevaluationindicatorforimproving the prognosisof patientswith livercirhosis，and stimulatingtheactionpathwayofIGF-Iorregulatingitsexpresionlevelmay becomeanewmethodforthetreatmentoflivercirhosis.Thisarticlereviews theresearchadvancesinIGF-Iinlivercihosis，in ordertoprovide new ideasfor the diagnosisand treatment of liver cirrhosis.

Keywords：Liver Cirrhosis；Hepatic Fibrosis;Insulin-Like Growth Factor I;Prognosis

Research funding：Gansu Province Scienceand Technology Major Project Plan（23JRRA1487

肝硬化是一種由多種慢性肝病發(fā)展而來的嚴(yán)重病理狀態(tài)，其特征是肝組織的彌漫性纖維化、假小葉形成及肝細(xì)胞的再生結(jié)節(jié)。（剩余19215字）