《2025年亞太肝病學會臨床實踐指南:代謝相關脂肪性肝病的診斷和管理》摘譯與解讀

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基金項目:國家重點研發(fā)項目(2023YFA1800801);國家科技重大專項(2023ZD0508700);國家自然科學基金(82070588,82370577)
Excerptand interpretationof theAsianPacificAssociationfortheStudyof theLiverclinicalpracticeguidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease in 2025
LEI Siyi 1,2 , LIAN Liyou I,2 , ZHENG Minghua1,2
1.DepartmentofInfectiousDiseases,TheFirstAfliatedHospitalofWenzhouMedical University,Wenzhou,Zhejiang35000 China;2.KeyLaboratoryofDiagnosisandTreatmentfortheDevelopmentofChronicLiverDiseaseinZhejiangProvince,Wenzhou, Zhejiang 325000,China
Corresponding author: ZHENG Minghua,zhengmh@wmu.edu.cn(ORCID: 0000-0003-4984-2631)
Abstract:SincetheAsia-PacificAssociationforthe Studyof theLiver(APASL)issuedtheclinical practiceguidelinesfor metabolicassociatedfattyliverdisease(MAFLD)in2O2O,theresearchonMAFLDhasbeenfurtherdeepened.Therefore,APASL has madecomprehensiveupdates andrevisions basedontheprevious guidelines,andthe latestversionof the clinical practice guidelinesfordiagnosisand managementof MAFLD,which wasreleased in February 2025,hasupdatedthe epidemiology, screning,asessent,and treatmentof MAFLD,aiming to promote theclinical practice,knowledge popularization,and scientificresearchofMAFLD.Thisarticlemakesan excerptandaninterpretationof theupdatedkeypointsoftheguidelines.
Key Words:Metabolic Dysfunction-AssciatedFattyLiver Disease;Diagnosis;Therapeutics;Practice Guideline
Research funding:National KeyR&DProgramofChina(2023YFA1800801);NationalScienceand TechnologyMajorProjec (2023ZD0508700); National Natural Science Foundation of China(82070588,82370577)
2020年亞太肝病學會(APASL)首先發(fā)布了代謝相關脂肪性肝?。∕AFLD)的診療指南[1(以下簡稱"2020版指南”),但亞太地區(qū)肝病負擔持續(xù)攀升,已成為全球肝病的主要原因,基于最新的研究證據,APASL在2020版指南的基礎上進行了更新與修訂,并于2025年2月在HepatologyInternational雜志上發(fā)布最新版MAFLD的診斷和管理臨床實踐指南[2(以下簡稱"2025版指南")。(剩余15213字)