前S1抗原乙型肝炎病毒DNA聯(lián)合乙型肝炎5項(xiàng)檢驗(yàn)用于乙型肝炎肝纖維化診斷的價(jià)值

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Thevalue of the pre-S1 antigen， hepatitis B virus-DNA combined with the hepatitisB 5-indicators test for thediagnosisin hepatitisB liver fibrosis

Huang Haiyan DepartmentofLaboratory，Pingdingshan CityHospitalofTraditional ChineseMedicine，Pingdingshan467o99，China

【Abstract】ObjectiveTo explore the effct of the pre-S1 antigen，hepatitis B virus （HBV）-DNA and hepatitisB 5-indicators for thediagnosis in hepatitis B liver fibrosis.MethodsIn12O patients with hepatitis B from August 2021 to February 2023，hepatitis pre-S1 antigen HBV-DNA and hepatitis B 5-indicators （HBsAg， HBeAg，HBcAb，HBsAb，HbeAb）.Using liver tissue pathological biopsy as the gold standard for diagnosing fibrosis，explore the diagnostic eficacy of the above indicators.ResultsAmong the12O patients included，41 patients did not experience liver fibrosis， accounting for 34.2% ，and were included as the non occurring group; 79 patients，accounting for 65.8%，developed liver fibrosis as the occurrence group.There were no statistically significant difference in the levels of HBeAb and HBsAb between the two groups （P>0.05 ）.Therewere statistically significant diference in the levelsof HBsAg，HBeAg，HBcAb，HBV-DNA，and pre S1 antigens between the two groups （ P <0.05）.The AUC values forboth singleand combined diagnosesare greater than O.7，with the combined diagnosis havingahigher value.ConclusionInthediagnosis of hepatitis Bliver fibrosis disease，thecombinationof spre-S1antigen，HBV-DNA and hepatitis B5-indicatorsare more effective than asingle diagnostic method and can be popularized.

【Key Words】Hepatitis B virus；DNA; Hepatitis B，surface antigens;Hepatitis B，e antigens; Hepatitis B， antibodies; Hepatic fibrosis；Pre-S1 antigen DOI：10.19522/j.cnki.1671-5098.2025.02.014

乙型肝炎主要是因乙型肝炎病毒（HBV）感染所致，極易誘發(fā)腎小球腎炎，臨床表現(xiàn)為血壓升高、水腫、血尿等，其中肝纖維化是本病進(jìn)展的重要病理過(guò)程[1]。（剩余6203字）