血清同型半胱氨酸尿酸腦鈉肽前體及尿微量白蛋白聯(lián)合檢驗在慢性腎小球腎炎輔助診斷中的應(yīng)用觀察

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【Abstract】ObjectiveTo explore the value serum homocysteine (HCY),uric acid (UA),N-terminal pro-brain natriuretic peptide(NT-proBNP)and urinary microalbumin (U-mALB)in the auxiliary diagnosis chronic glomerulonephritis (CGN).MethodsSixty CGN patientsand sixty healthy physical examination patients admitted toour hospital from January 2O2Oto January 2O23 were selectedas the observation groupand the control group.Allblood samples were collected forHCY,UA,andNT-proBNP levels,andurine collection forU-mALB levels.Comparing HCY,UA,NT-proBNP and U-mALB levels between the two groups,and the diffrences CGN patients with different stages.ROC curve was used to analyze the clinical value each index to diagnose CGN. ResultsThe levels HCY,UA,NT-proBNP and U-mALB in the observation group [(19.0±1.5) μmol/L, (490 ± 43)μmol/L,(446±52)pg/ml,(32.6±3.5)mg/L],were higher than those in the control group[(9.2±1.2) μmol/L, (306±30) μmol/L, (201±20) pg/ml,(14.1±1.2) mg/L (P<0.05) ]; The levels HCY,UA,NT-proBNPand U-mALB instageIICGN patients [(25.7±2.3)μmolL,(543±50)μmol/L,(502±55) pg/ml, (40.52±4.19) mg/L] were higher than those in stage I and stage I CGN patients (P
【Key words】Glomerulonephritis;Homocysteine;Uric acid;Natriueretic peptide,brain;Urinary microalbumin;Diagnotis DOI:10.19522/j.cnki.1671-5098.2025.02.013
慢性腎小球腎炎(chronicglomerulonephritis,CGN)為常見腎臟病變,好發(fā)于中年男性群體,在腎小球損傷過程中,會影響腎臟的正常代謝,誘發(fā)血尿、蛋白尿、水腫等多種癥狀,一旦治療不及時,腎損傷可持續(xù)進(jìn)展,最終可導(dǎo)致尿毒癥的發(fā)生,降低患者生存質(zhì)量。(剩余6217字)