磁共振彈力值對非酒精性脂肪性肝病患者肝纖維化的定量評估及其與堿性磷酸酶天冬氨酸轉(zhuǎn)氨酶的關(guān)系

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Quantitativeevaluationof liver fibrosis inpatientswith nonalcoholic fatty liver diseasebymagnetic resonance elastographyand its relationship with alkaline-phosphatase，aspartate-aminotransferase Lu Zhipeng

MedicalImagingDepartment，Zhengzhou People'sHospital，Zhengzhou45ooO3，China

【Abstract】ObjectiveTo analyze the quantitative evaluation of magnetic resonance elastography （MRE） values inassessing liver fibrosis in patients with non-alcoholic fatyliver disease（NAFLD）and to investigate its relationship with alkaline phosphatase （ALP）and aspartate aminotransferase （AST） levels.MethodsFifty patients with NAFLDadmitted toour hospital from January 2023 to December 2O23 were analyzed.Routine abdominal， magnetic resonance elastography （MRE），ALP and AST were detected before operation，and the clinical data of he patients were analyzed.ResultsTheresults showed that the degree of liver fibrosis was divided into 7cases of non-fibrotic stage（SO），12 cases of mildfibrotic stage （S1），12cases of significantfibrotic stage （S2），11casesof advanced fibrotic stage（S3）and8casesof cirrhosis stage（S4）.InNAFLDpatients，there were significant diferences in livermagneticresonance elasticityvalues inthediagnosis of mild liver fibrosis，significant liverfibrosis，advanced liver fibrosis and cirrhosis （all P<0.05 ）.The accuracy of MRI elasticity values in the diagnosis of mild liver fibrosis， significantliverfibrosis，advancedliverfibrosisandcirhosiswere0.90（95%CI0.81，0.96），0.91（95%CI0.83，0.98）， 0.93（95%CI 0.86，1.0）and 0.93（95%CI 0.84＼～），respectively1.00）.Among them，the sensitivityof livercirhosis was thehighest;forthediagnosisofmildliverfibrosis，thespecificitywasthe greatest.Pearsonlinearcorelationanalysis showed that in NAFLD patients，there was no significant correlation between liver magnetic resonance elasticity value and totalbilirubin，globulin，total proteinandalbumin（r=0.191，0.122，0.262，0.153，P>0.05），andthere wasa weak positive correlation with ALP（r=O.447，P

ConclusionMREcanbeusedasanefective evaluation tool for liver fibrosis inNAFLDpatients，and it is corelated with ALPand AST.Especially in the diagnosis of cirhosis，MREshows high sensitivityand is of great significance for earlydiagnosisand therapeutic intervention.

【Key words】Non-alcoholic fatty liver disease；Elasticity imaging techniques；Hepatic fibrosis；Alkaline phosphatase; Aspartate aminotransferases DOI：10.19522/j.cnki.1671-5098.2025.02.005

非酒精性脂肪性肝?。╪on-alcoholic fattyliver disease，NAFLD）是一種常見的代謝性疾病，其特征是肝臟內(nèi)脂肪積累超過正常范圍，沒有其他顯著的酒精消耗史或其他明顯的肝病因素。（剩余6919字）