TBIL、GGT及Hb預(yù)測高膽紅素血癥新生兒 并發(fā)急性膽紅素腦病的價(jià)值
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[Abstract]Objective： To analyze the value of TBIL， gamma-glutamyl transpeptidase （GGT），and Hb in predicting acute bilirubin encephalopathy （ABE）in neonates with hyperbilirubinemia.Method：Eighty neonates with hyperbilirubinemia admitted to the Shangrao People's Hospital from September 2O21 to September2024 were selected，and divided into group A （without ABE）and group B（with ABE）according to whether ABE occurred during one month of follw-up.Liver function indicators （IBIL，TBIL，GGT，ALT），blood routine indicators[Hband albumin （ALB）]，and TBIL/ALB （B/A） values in the two groups were compared. The relationship between above indicatorsand the occurrence of ABE in neonates with hyperbilirubinemia was analyzed.The ROC curves were used to evaluate the predictive value of liver function indicators and blood routine indicators for ABE in neonates withhyperbilirubinemia.Result：Atotal of 31 cases（ 38.75% ）neonates with hyperbilirubinemiadeveloped ABE. IBIL，TBIL，GGT，ALT， Hb，and B/A in group B were significantly higher than those in group A，ALB was significantly lower than thatin group A，with statistical significance （ P <0.05）.Point two-column correlation analysis showed that TBIL，GGTand Hb were positivelycorrelated with ABE in neonates with hyperbilirubinemia （ r>0 ， P <0.05）.However，there were no significant correlation between IBIL，ALT，ALB，B/A with ABE in neonates with hyperbilirubinemia（ P>0.05 ）.TheAUC of TBIL，GGT，andHb for predicting ABE inneonates with hyperbilirubinemia were 0.769， 0.683，and 0.657 'P<0.05 ）. The AUC of TBIL was the largest. Conclusion：Early TBIL，GGT，and Hb inneonates with hyperbilirubinemia are closely related to theoccurrence of ABE.The three have high predictive value for ABE， especially TBIL.
[Keywords] Total serum bilirubin Gamma-glutamyl transpeptidaseHemoglobinHyperbilirubinemia Acute bilirubin encephalopathy
高膽紅素血癥又稱為黃疸，多因機(jī)體膽紅素生成與分解速度未能平衡所致，主要癥狀表現(xiàn)包括皮膚黏膜或鞏膜出現(xiàn)黃染現(xiàn)象，在無其他因素的影響下消退速度一般較快，且低濃度的膽紅素還可產(chǎn)生抗氧化及免疫調(diào)節(jié)作用[1。（剩余5776字）