重復(fù)經(jīng)顱磁刺激聯(lián)合右佐匹克隆對帕金森睡眠障礙患者睡眠質(zhì)量的影響

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Effects of Repetitive Transcranial Magnetic Stimulation Combined with Eszopiclone onSleepQualityinPatientswith Parkinson'sDiseaseand SleepDisorders

LI Jing，LI Ruixia

（DepartmentofNeurology，TheAfliated Hospitalof Nanjing UniversityMedical School，Suzhou215ooo，China）

AbstractObjective：Toivestigatetheefectsofrepetitive transcranialmagneticstimulationcombinedwith eszopicloneonsleep qualityandneurotransmiterlevelsinpatientswithParkinson'sslepdisorders.Methods：Atotalof63patientswithParkinson's diseaseandslpdisodersadmittedtotheAflatedHospitalofNanjing UniversityMedicalScholfromJune2O22toJune2024 wereselectedas theresearch subjects.Theywererandomlydividedintoacontrolgroup（3Ocases）andanobservationgroup（33 cases）acording toarandomnumbertable method.Thecontrolgroupreceived eszopiclonetreatment，whiletheobservationgroup receivedrepetitivetranscranialmagneticstimulationtherapyandeszopiclone.Thetreatmentperiodwas4weks.ThePisburgh SleepQuality Index（PSQI）was usedtocompare thediferences insleepqualitybetwen two groups.The Insomnia Severity Index （ISI）wasused to evaluate thedegreeof insomnia beforeandafter treatmentinthetwo groups.Theself-made Parkinson'sdisease sleepscalewasusedtocomparethe symptomimprovement efectsof thetwo groups，andtheincidence ofadverse events wascompared.Results：Aftertreatment，the PSQI scoresand ISIscoresofthe observation groupwere significantlylowerthanthoseof the controlgroup，andthe Parkinson's disease sleepscale scores were higherthan thoseofthecontrol group.The diferences betwen the two groups were statistically significant（ P<0.05 ）；There were no statistically significant differences in the incidence of adverse events between the two groups（ P>0.05 ）. Conclusion： Repetitive transcranial magnetic stimulation combined with eszopiclonecanefectively improvethesleepqualityandalleviateinsomniasymptoms inpatientswitharkinson'sdiseaseandsleepdisorders，and is worthy of clinical promotion and application.

KeywordsParkinson's disease；Sleepdisorders；Repetitive transcranial magnetic stimulation；Eszopiclone；Sleepquality 中圖分類號：R338.63 文獻(xiàn)標(biāo)識碼：A doi：10.3969/j. issn.2095-7130.2025.02.014

帕金森病的臨床表現(xiàn)包括不自主的顫抖、行動遲緩等標(biāo)志性運動癥狀，同時還可能引發(fā)睡眠障礙等非運動癥狀，這些癥狀嚴(yán)重干擾患者的日常生活，降低其生命質(zhì)量[1]。（剩余5790字）