分析神經(jīng)節(jié)苷脂鈉聯(lián)合高壓氧對顱腦損傷術(shù)后昏迷患者早期促醒效果及睡眠質(zhì)量的影響

打開文本圖片集

Analysis of the Early Wake-Up Efect and Sleep Quality Improvement of Ganglioside Sodium Combined with Hyperbaric Oxygen on Patients with Coma after Craniocerebral Injury Surgery

（Huai'an 82nd Hospital，Huai'an 223600，China）

AbstractObjective：Toinvestigate theefectSof ganglioside（GA）combined withhyperbaricoxygen（HBO）onearlyawakening anditsimpactsonslpqualityinpatientswithcomaaftercraniocerebralinjurysurgery.Methods：Atotalof89postoperativecomatosepatients with craniocerebral braininjuryadmited tothe Neurosurgery DepartmentofHuai'an 82nd HospitalfromJanuary 2019 to January 2O24 were selected as the study subjects.They were randomly divided into a control group（ n=42 ）and an observation group（ n=47 ）using a random number table method. The control group received routine postoperative management and GA treatment，while theobservation groupreceived HBOandGA treatment.The Pitsburgh Sleep Quality Index（PSQI）was used to comparethechanges insleepqualitybeforeandafter interventionbetweentwogroups.Thechangesinbloodflowvelocity，awakeningtime，and neurologicalfunctionindicatorsbetweenthetwo groups werecompared.The incidenceof adverseevents wasalso comparedbetweenthetwo groups.Results：After treatment，theawakening timeof theobservationgroup wassignificantlyshorter thanthatof thecontrolgroup.Theintracranial midlecerebralartery（MCA）bloodflowvelocityoftheobservation grouppatients wassignificantlylowerthanthatofthecontrolgroup.ThePSQIscoresof theobservationgrouppatientsweresignificantlylower thanthoseofthecontrolgroup.Thebrain-derivedneurotrophicfactor（BDNF）levelsoftheobservationgrouppatients weresignificantlyhigherthanthoseofthecontrolgroup，andthecerebrospinalfluidnorepinephrine（NE）levelsweresignificantlylowerthan thoseof thecontrol group.Theincidenceofadverseeventsintheobservationgroupwassignificantlylower than thatof hecontrol group，and the differences between the two groups were statistically significant（ P<0.05 ）. Conclusion： GA combined with HBO treatmentforcomatosepatientsaftercraniocerebralbraininjurysurgerycansignificantlyshortentheawakeningtime，improve sleepquality，promoteneurological functionrepair，and hasgoodsafety.Itisworthyof clinical promotionandapplication.

KeywordsComa;Brain injury;； Ganglioside; Hyperbaric oxygen；Awakening; Slpquality；Adverse events；Neurological function

中圖分類號(hào)：R651.1+5;R338.63 文獻(xiàn)標(biāo)識(shí)碼：A doi：10.3969/j. issn.2095 -7130.2025.02.013顱腦損傷是臨床常見的嚴(yán)重疾病，其術(shù)后昏迷 狀態(tài)對患者預(yù)后具有重要影響[1]。（剩余4631字）