膽汁酸抑菌機(jī)制及結(jié)構(gòu)改性的研究進(jìn)展

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中圖分類號(hào)：S859.797 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：0366-6964（2025）06-2546-09

Research Progress in Antimicrobial Mechanism and Structural Modification of Bile Acids

PAN Hua123， SUN Lei4， ZHANG Jun1，2，3*，LIU Lili1，23， MA Wengang1，2，3， CAO Aizhi1，2，3， LU Mingbin1，2，3 （1.Longchang Animal Health Products Co.，Ltd， Dezhou 2530o，China;2.Bile Acids Animal Health Dezhou Engineering Research Center，Dezhou 253Ooo，China；3.Dezhou Bile Acids R&D and Application Key Laboratory， Dezhou 25300o，China ;4. Longkou Animal DiseaseControl Center，Yantai 264OOO，China）

Abstract： Bile acids，as a natural substance that inhibits the growth of microorganisms in animals，is gaining increasing attention. Currently，there is stilla lack of systematic analysis of the diversity of antibacterial mechanisms of bile acids. In this review，the latest progress in the study of the antibacterial mechanism of bile acids，including the direct antibacterial mechanism （surfactant mechanism，destroying cell membrane homeostasis mechanism and oxidative damage mechanism），and the indirect antibacterial mechanism （activating the expression of host antibacterial substances and affecting the expression of bacterial functional genes）. On this basis，the structural modification strategies （dimerization/polymerization，introduction of positively charged groups and synthetic biology of secondary bile acids） to improve the antibacterial activity of bile acids were summarized，with a view to providing theoretical reference and basis for the application of bile acids in bacteriostasis.

Keywords：bile acids;antimicrobial mechanism;structural modification ? Corresponding author： ZHANG Jun，E-mail： zhangjun841O13@aliyun. com

近年來，畜牧養(yǎng)殖業(yè)面臨耐藥性病原菌日漸流行的問題，而傳統(tǒng)抗生素的應(yīng)對(duì)措施日漸乏力，由此推動(dòng)了新型抗菌物質(zhì)的探索[。（剩余17506字）