桑芪首烏方對(duì)高血壓早期腎損害血管內(nèi)皮功能影響的臨床觀察

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【中圖分類號(hào)】R289.5 【文獻(xiàn)標(biāo)志碼】A 【文章編號(hào)】1007-8517（2025）10-0115-04

DOI： 10.3969/j . issn.1007-8517. 2025.10. zgmzmjyyzz202510022

Clinical Observation of the Effect of Sangqi Shouwu Formula on Vascular Endothelial Function inEarlyRenal Damage ofHypertension

GUO Shiyu1WEI Danxia1 LI Dongyun1HU Zhiyu1*LI Huijuan2 1.KunmingHospital of Traditional ChineseMedicine，Kunming 65OO11，China; 2.Yunnan University of Traditional ChineseMedicine，Kunming 65O5OoO，China

Abstract：ObjectiveToinvestigatetheefectofSngqishouu Decoctiononvascularendothelialfunctioninearlystageofrenal damageinhypertension.Methods72patientswithearlyrenaldamageofhpertensionadmitedtotheDepartmentofNephologyand Rheumatism weredivided intotwogroupsaccording torandomnumbertablemethod，36cases ineach group.Thecontrolgroupwas treatedwithirbesartantabletandthetreatmentgroupwastreatedwithSangqishouuprescriptiononthebasisofIrbesartantablet. The course of treatment was 4 weeks. The serum levels of endothelin -1 （ET-1）and nitric oxide （NO） in the two groups were compared，andteotalectiveatefetwogrousasulatedResultsftertreament，televelofETinthtreantgoup was lower than that in the control group （ P<0.05 ），the level of NO and the total eective rate were higher than that in the control group （ P<0.05 ）.Conclusion Sangqi shouwu formula can improve vascular endothelial function in patients with early renal damage of hypertension，and the effect is outstanding.

Key words：Sangqi shouuu Decoction；Early Renal Damage in Hypertension；Vascular Endothelium；ET-1；NO

高血壓是全球內(nèi)重大公共衛(wèi)生問(wèn)題，長(zhǎng)期以來(lái)大眾對(duì)高血壓治療的認(rèn)識(shí)存在誤區(qū)，導(dǎo)致血壓控制不理想、不達(dá)標(biāo)，日久累及多個(gè)靶器官損害。（剩余5372字）