驢鞭肽輔助修復(fù)SD雄性大鼠性功能損傷作用的研究

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【中圖分類號(hào)】R285.5 【文獻(xiàn)標(biāo)志碼】A 【文章編號(hào)】1007-8517（2025）10-0040-07

DOI： 10.3969/j .issn.1007-8517.2025.10.zgmzmjyyzz202510008

Study on the Effect of Donkey Whip Peptide on the Repair of Sexual Function Injury in SD Male Rats

ZHENG Liping'YAN Yongqiu2YU Xindi2WANG Pengze2MA Yurong'ZHANG Haixin'CUIPengleil*LI Guoming1* 1.BeijingEngineringResearchCenterofProteinandFunctionalPeptides，ChinaNationalResearchIstiuteofFod&Fetation Industries，Beijing 10015，China；2.Ningbo Yufangtang Biology Technology Co.，Ltd.，Ningbo 315012，China

Abstract：ObjectiveToinvestigatetherepairefectof donkeywhippeptideonmaleratswithsexualdysfunction.MethodThe amino acidcompositionandmolecular weight distributionofdonkeywhippeptidewere aalyzed.SDratswereselectedtoestablisha maleratmodelofsexualdysfunction.Diferentconcentrationsofdonkeyhippeptidewereusedtointervneinthismodel.Theweight oftheratswasrecorded，andthetesticularandrenalindiceswere measured.Enzymelinkedimmunosorbentassaywasusedtodetect thelevelsofT，LH，andNOintheserumofrats.Tepathologicalmorphologyof kidneyandtestistisuesinratswasobservedby hematoxylin eosin（HE）staining.Results Donkeywhippeptidehasarichvarietyofamino acids，with argininecontentof 7.52% （20 and molecular weight below 1OoO u accounted for 79. 44% .Compared with the model group，the intervention group with donkey whip peptideshowedanincreaseinbodyweight，testicularindex，andrenalindex，aswellasasignificantincreaseinserumlevelsofT， LH，andNO.Thepathological morphologyof thekidneysandtesteswasalsoimproved.ConclusionDonkeywhippeptidehasarich aminoacidcomposition，highnutritonalvalue，andiseasytoabsorb.Itcaniprovethsexualelatedrganindexofatswithexual dysfunction，promotethsecretioofserumeutralelatedfactos，mproveideyandtesticularlsios，andhavetefeofs sisting in repairing sexual dysfunction.

KeyWords：DonkeyWhip Peptide；Sexual Dysfunction；Testosterone；Nitric Oxide；Luteinizing Hormone

男性性功能衰退現(xiàn)已成為常見病癥，如射精功能異常、勃起異常、性欲低下等，嚴(yán)重者會(huì)對(duì)生育功能造成影響[1-2]。（剩余8029字）