基于生物信息學(xué)的阿爾茲海默病線粒體相關(guān)Hub基因的篩選

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中圖分類號(hào)：R749.1 文獻(xiàn)標(biāo)識(shí)碼：A文章編號(hào)：1006-1959（2025）09-0001-07

Abstract：OeiTeihodalbodissfoatilsdalctio. MethodsTeAeimersdseasegenechipdatasetasdowloadedfrotheGEOdatabaseoftheNatioalCenterforBiotechologInfotion theUnitedStateeubsoferiseaseesedtouhdieretialexpresoaalysisdweightednpon networkaalysiseitoondialrelatedgnsraidfroteitCarta3dtabasedinterseedittforemetiodubees. Theintersectiongnsweeechedandaalyed，andaproteininteractioetworkaonstructedusingteStringdtabase.Tesulsre importedintoCytoscapesoftwareandtetop6gnsrankedinDegrewerescrendusingtheCCalgorit.ResultsAtotalof38down regulatedgenesdaedseedetialexpressolotalofseeyde co-expressooalysdolddioaGtal showedthatitasainlyolediloicalroceuchsangsiniochodrialorpeplicatioofiocodalo synthesisfniochodrialompoentsnditocondialaterialtrasportKGGpathaichentalysissodatitsinly enrichdnaroo‘scidabdsttaboallod relatedtoAlzier‘sseaseereeedbCyaesoftare：C，UFABPOosioo Alzheimersdiseaseenetasdobidwirityoffoatialsetosiitohodralubnsetied which can provide atheoretical basis for the role of mitochondrial dysfunction in Alzheimer's disease.

Keywords：Bioinformatics;Alzheimer'sdisease;Mitochondria;Hub genes

阿爾茲海默?。ˋlzheimer'sdisease，AD）是一種常見于老年和老年前期的中樞神經(jīng)系統(tǒng)退行性疾病，以進(jìn)行性認(rèn)知功能障礙和行為損害為主要特征，臨床上以性格改變、幻覺、妄想、猜疑和情緒不穩(wěn)等精神癥狀為表現(xiàn)I。（剩余11556字）