基于FAERS數(shù)據(jù)庫(kù)進(jìn)行伊布替尼藥物不良事件信號(hào)挖掘

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AdverseDrugEvent SignalsMiningof IbrutinibBased onFAERSDatabase

LIAiguo1，CHENXianglei2

（Department of Blood Transfusion1，Departmentof Hematology2，Yidu Central Hospital of Weifang，

Qingzhou ，Shandong，China）

Abstract：ObjectiveTexplorethedversedrugevent（ADE）sigalsofiutibyusingteFoodandDrugAdminstration（FD）AdvereEvent ReportingSyteERndoovideeferecefolcaltioalgseetdsataofutirthisuartef firstuarteofiedeporigddaofealrogessal wereusedforsignalminingtoaalyzetheoureneofADE.ResultsAtotalof583Oreportsofadverseeventsithbutinibastepriary suspecteddrugeredeedTedauefeseeactiosfiutibs4aysnlyinearlyaofat andADEreportigodnceasingtrendaryaDEigalsre58oling5anasitio（OC）Coio therealworldibsderseetseranduglbelsndlcefochdveseeetsouldmprovdtoeue safety of patients.

KeyWords：Ibrutinib；TheFoodandDrugAdministrationAdverseEventReporting System；Adversedrug event

布魯頓酪氨酸激酶（bruton tyrosine kinase，BTK）廣泛參與B細(xì)胞的增殖、分化與凋亡，是惡性血液腫瘤的重要治療靶點(diǎn)。（剩余8232字）