NLR、PLR、RDW聯(lián)合IL-6在AECOPD預(yù)后不良中的意義及其預(yù)測效能分析

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Significance of NLR， PLR， RDW Combined with IL-6 in Poor Prognosis of AECOPD and Its Predictive Effcacy Analysis/CHEN Zhaodi， YOU Jianhua， XIE Wenqi. //Medical Innovation of China， 2025， 22（12）： 144-148

[Abstract]Objective： To analyze the predictive value of neutrophil-to-lymphocyte ratio （NLR）， plateletto-lymphocyte ratio （PLR），red cell volume distribution width （RDW）combined with interleukin-6 （IL-6）in poor prognosis of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Method： A total of 50 patients with AECOPD treated inthe FirstPeople's Hospital of Fuzhou from June 2022 to June 2024 were selected as the studyobjects.Thevenous blood samplesofallpatients werecollected，thelevelsofneutrophil，lymphocyte， platelet，RDW and IL-6 were detected， NLR and PLR were calculated， andthe predictive valueof NLR，PLR，RDW combined with IL-6 in the poor prognosis of AECOPD were analyzed. Result：Among the 50 patients with AECOPD， 39 survived， with a survival rate of 78.00% . Compared with the death group， the levels of NLR， PLR， RDW， IL-6 and proportionof smoking history in the survival group were lower，and theage was young，thedifferences were statistically significant （ P <0.05）. logistic regresson analysis showed that NLR， PLR， RDW， IL-6， age and smoking history were all influencing factors for the poor prognosis of AECOPD （ . The area under the curve （AUC） of NLR， PLR， RDW and IL-6 in predicting poor prognosis of AECOPD were 0.660， 0.765， 0.618 and 0.697， respectively.The AUC，sensitivityand specificity ofthecombination of NLR，PLR，RDWand IL-6 in predicting the poor prognosis of AECOPD were 0.810， 81.56% and 84.24% ，respectively. Conclusion： NLR， PLR， RDW， IL-6， age and smoking history are allinfluencing factors for the poor prognosis of AECOPD， and NLR， PLR， RDW combined with IL-6 has high efficacy in predicting the poor prognosis of AECOPD.

[Key words]Neutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioRed cell volume distribution widthInterleukin-6 Acute exacerbation of chronic obstructive pulmonary disease Poor prognosis

First-author's address： Department of Clinical Laboratory， First People's Hospital of Fuzhou， Fuzhou 344000， China

doi：10.3969/j.issn.1674-4985.2025.12.035

慢性阻塞性肺疾?。╟hronic obstructive pulmonarydisease，COPD）作為老年群體常見疾病，具有較高的發(fā)病率、患病率，且在近年來呈上升趨勢。（剩余5289字）