四孔腹腔鏡穿孔修補術(shù)用于胃十二指腸潰瘍急性穿孔患者的效果及安全性

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Efficacy and Safety of Four-hole Laparoscopic Perforation Repair in Patients with Acute Perforation of Gastroduodenal Ulcer/QU Tao. //Medical Innovation of China， 2025， 22（12）： 021-024

[Abstract]Objective： To investigate the clinical effct of four-hole laparoscopic perforation repair in patients with acute perforation of gastroduodenal ulcer. Method： A total 60 patients with acute perforation of gastroduodenal ulcer admitted to from December 2022 to December 2024 were retrospectively analyzed anddivided into two groups according todiffrent surgical methods， with 30 cases in each group.The control group underwent traditionallaparotomy repair，and the observation group underwent fourhole laparoscopic perforation repair.Perioperative indexes， pain degree， inflammation indexes and complication rate between the two groups were compared. Result：The operation time， anal exhaust time，geting outof bed time， hospitalization time and incision length in theobservation group were shorter than those inthe control group， and the intraoperativebloodloss was less than that in the control group，the differences were statistically significant 0 P <0.05）.At6，24and 48h after operation， visual analogue scale （VAS）scores in theobservation groupwere lower than those in the control group， the differences were statistically significant （ P <0.05）.Before operation， there were no significant differences in inflammation indexes between the two groups （ P >0.05）. On the first day after operation， the hypersensitive C reactive protein （hs-CRP）and white blood cellcount （WBC）in the observation group were lower than those in the control group， the differences were statistically significant （ P <0.05）. The complication rate of the observation group was lower than that of the control group，the diference was statistically significant （ P <0.05）. Conclusion： Compared with traditional open repair，four-hole laparoscopic perforation repair for acute perforation of gastroduodenal ulcris moreeffective inoptimizing perioperative indexes，alleviating inflammation and pain， and reducing complications.

[Key words] Gastroduodenal ulcer Acute perforation Four-hole laparoscopic perforation repair Perioperative index Pain degree Inflammation index Complications

First-author's address： Gastrointestinal Hernia Surgery， . iupanshui 553000， China doi： 10.3969/j.issn.1674-4985.2025.12.006

胃十二指腸潰瘍指發(fā)生在胃或十二指腸的慢性潰瘍性病變，通常由胃酸、胃蛋白酶的消化作用引起，當(dāng)潰瘍病灶向深部發(fā)展，穿透胃或十二指腸的漿膜層時，即會引起急性穿孔，若未及時治療，嚴(yán)重時會導(dǎo)致感染性休克，甚至危及生命-2。（剩余4967字）