連續(xù)性血液凈化、血漿置換輔助治療噬血細(xì)胞性淋巴組織細(xì)胞增生癥患兒的效果

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Effect of Continuous Blood Purification Plasmapheresis in the Adjuvant Treatment of Hemophagocytic Lymphohistiocytosis/GE Xiaofeng， NI Jia， TANG Rong. //Medical Innovation of China， 2025，22（12）： 005-008

[Abstract]Objective： To analyze the effect of continuous blood purification plasmapheresis in the adjuvant treatment ofhemophagocyticlymphohistiocytosis （HLH）.Method：A totalof 50children withHLH treated in from January to December 2023 were selected as the study objects divided into two groups according to rom number table method.The control group received basic treatment， the observation group received continuous blood purification plasmapheresis onthe basis ofthe control group.The clinicalefficacyinterleukin-6 （IL-6），interleukin-10（IL-10），interleukin-12（I-12）the incidenceofcomplications werecomparedbetween thetwo groups.Result：Thetotalefectiverateoftheobservation group was 88.00% ， which was higher than 60.00% of the control group， the difference was statistically significant =5.094， P =0.024）.After 4 weeks of treatment， the levels of IL-6， IL-10 IL-12 in the observation group were lower than those in the control group， the differences were statistically significant （ P<0.05） .The total incidence of adverse reactions in the observation group was 16.00% ， which was lower than 48.00% in the control group， the difference was statistically significant （ P=0.015 ）. Conclusion： Continuous blood purification

① 貴陽市婦幼保健院兒童重癥醫(yī)學(xué)科貴州貴陽550001 通信作者：葛曉風(fēng)

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plasmapheresis have good effct intheadjuvanttreatmentof HLHchildren，whichcan significantlyreduce thelevels of inflammatory factors reduce the incidences of complications.

[Key words] Continuous blood purification Plasmapheresis Chemotherapy Hemophagocytic lymphohistiocytosis Complication

First-author's address： Department of Intensive Medicine， Maternal ， 550001， China doi：10.3969/j.issn.1674-4985.2025.12.002

噬血細(xì)胞性淋巴組織細(xì)胞增生癥（hemophagocyticlymphohistiocytosis，HLH）是一種有潛在致命性的免疫調(diào)節(jié)障礙疾病，其特征是免疫系統(tǒng)過度激活，導(dǎo)致炎癥細(xì)胞過度增生和活化，進(jìn)而影響多個器官系統(tǒng)。（剩余5415字）