度拉糖肽對(duì)2型糖尿病合并肝硬化患者血糖 水平、肝硬化指標(biāo)的影響

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Effects of Dulaglutide on Blood Glucose Levels and Liver Cirrhosis Indexes in Patients with Type 2 Diabetes Mellitus Complicated with Liver Cirrhosis/ ， ， ， ， .//Medical Innovation of China， 2025， 22（12）： 013-016

[Abstract]Objective：To analyzethe effcts of Dulaglutide on blood glucose and liver cirrhosis indexes in patients with type 2diabetes mellitus.Method：A total of 80patients with type2diabetes melltus complicated withliver cirrhosis admitted to Ganzhou Fifth People's Hospital from January to December 2022were selected as the study objects， and they were divided into control group and observation group by random drawing method， with 40 cases in eachgroup.The control groupwas treated with insulin，and the observation groupwas treated with Dulaglutideonthe basisof the controlgroup.Blood glucose andlivercirrhosis index were compared between the two groups.Result： Onthe 30th， 90th and18Othdays oftreatmentand1 year after treatment， the fasting blood glucose （FBG） and 2 h postprandialblood glucose （2 h PBG）levels inthe observation group were lower than those in the control group， the differences were statistically significant （P<0.05 ）. On the 18Oth days of treatment and 1 year after treatment，theliver stiffness measurement（LSM）of theobservation group werelowerthan those of the control group， the differences were statistically significant （P<0.05） . Conclusion： Dulaglutide can improve blood glucose levels and

基金項(xiàng)目：江西省衛(wèi)生健康委科技計(jì)劃項(xiàng)目（202511103）

① 贛州市第五人民醫(yī)院腎內(nèi)內(nèi)分泌科江西 贛州341000

② 贛州市第五人民醫(yī)院精神科江西贛州 341000通信作者：鄧鵬

liver function in patients with type 2 diabetes mellitus complicated with liver cirrhosis.

[Key words] Dulaglutide Type 2 diabetes melitus Liver cirrhosis Blood glucose Liver stiffness measurement

First-author's addres： Department of Nephroendocrine， Ganzhou Fifth People's Hospital， Ganzhou 341000， China

doi：10.3969/j.issn.1674-4985.2025.12.004

2型糖尿病是由多種原因?qū)е聶C(jī)體內(nèi)胰島素分泌不足或胰島素利用障礙，導(dǎo)致機(jī)體血糖水平持續(xù)高于正常范圍，損傷機(jī)體血管、神經(jīng)等，危害心、肝、腎等器官功能的內(nèi)分泌性疾病[1-2]。（剩余4551字）