琥珀酰化在腫瘤發(fā)生發(fā)展中的作用機(jī)制研究進(jìn)展

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esearch progress on the mechanism of succinylation in tumorigenesis and development

Su Xiayi1'2，Bai Jie1，3，Zhang Baihong1，Liu Yong2 （20號(hào) 1 The940thHospitalofJintLgsticsSupportForceofPeople'sLiberationAryLanzhou73oO；2DepartmentofMedicine，orthest MinzuUniversity，Lanzhou3O3o；theFirstchoolofClinicalMedical，GansuUniversityofChinseMedicine，Lanzhou0000 **Corresponding author；Liu Yong，email：yliu668 @ 126. com

[Abstract]Succinylationisapost-translationalmodificationprocessthatplaysacrucialroleinregulatingproteinstructure andfunctionandisimplicatedinthepathogenesisofvariousdiseases.Emergingevidencesugeststhatsucinlationcontributesto tumorprogresionbymodulating metabolicreprogrammingandinfuencingtheexpresionof targetproteingenes.Thesealeratioscan significantlyimpacttumordevelopmentandprogresio.Tiseviewimstosummarizethemechanisticoleofsuccylationinorgenesis，providing insights into itspotential asa biomarker forcancer diagnosisandatargetfortherapeutic intervention.

[Key words] Succinylation modification；Metabolic reprogramming；Tumor；Targeted therapy；Post-translational modification

翻譯后修飾（Post-translational modification，PTM）是對(duì)翻譯后蛋白質(zhì)中氨基酸側(cè)鏈的共價(jià)修飾，可通過(guò)調(diào)控蛋白質(zhì)的折疊、活性、穩(wěn)定性、定位、信號(hào)傳導(dǎo)和結(jié)合來(lái)擴(kuò)大蛋白質(zhì)功能的多樣性[1]。（剩余9772字）