楊樹桑黃菌次生代謝產(chǎn)物及其生物活性研究

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Study on secondary metabolites and their biological activities Sanghuangporus vanini

Liu Xuwen，ZhouJie，Ye Dongyan，Li Qianhui，YinShuren，Xu Ziwen，Liu Dan，NurbiyamNurmamat，andBai Helong （College ， ， 130032）

Abstract Objective To study the chemical composition and biological activity solid culture Sanghuangporus vaninii.MethodsThe compounds were isolated and purified by ultrasonic extraction and semipreparative liquid chromatography.Their structures were identified by NMR data，and their inhibitory activities against a -amylase and a -glucosidase were evaluated. ResultsSeven compounds were isolated from the extract Sanghuangporus vaniniiand identified as hispidin （1），scopoletin （2），phellifuropyranone A （3）， penilactone D （4），（ 3E. 6S）-3-heptene-1，6-diol （5），ethylorselinate （6），4-（2-hydroxyethyl）benzene-1，2-diol （7）. The inibitory activity a -amylaseand a -glucosidase showed that compound2 had strong inhibitory activity against a -amylase and （204號 a glucosidase.The inhibition rates compound 2 on the two enzymes were 82% and 68% ， respectively， and the IC50 was 29.28μmol/L and 61.28μmol/L ， respectively. It showed mixed inhibition a -amylase and competitive inhibition a -glucosidase.ConclusionThis study enriched the chemical composition and biological activity the solid culture Sanghuangporus vanini， and provided a basis for its further development and application.

Key wordsSanghuangporus vanini; a -amylase; a -glucosidase; Inhibition type

桑黃是一種珍貴的多年生藥用真菌[1]，據(jù)記載，桑黃又名桑耳、桑臣和桑黃菇等[，有“森林黃金”之美稱[3]，主要生長在桑樹、柳樹和樺樹等闊葉樹的樹干或樹樁上[4]。（剩余11528字）