核因子 -κB 白細(xì)胞介素-17及趨化因子受體1水平對哌拉西林/他唑巴坦治療兒童社區(qū)獲得性肺炎療效的預(yù)測研究

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PredictionofNF- κκB ，IL-17and CXCR1levelsonthe efficacyof piperacillin/tazobactam in the treatmentof children with communityacquired pneumonia

WuXiaozhen，JiaJunfang，F(xiàn)engRuina

DepartmentofPediatricIntrenalMedicine，LinyingCountyMaternalandChildHealthCareHospital，Luohe462600，

China 【Abstract】 Objective To investigate the relationship between nuclear factor-KB（NF-kB），interleukin-17 （IL

-17）andchemokinereceptor1（CXCR1）ontheeffectsof piperacilln/tazobactamonchildrenwith communityacquired pneumonia.MethodsA total of 90 children who received piperacilin/tazobactam in the treatmentof CAP in Linying County Maternal and Child Health Hospital from January to December 2O23 were retrospectively selected，and divided into effective group （ n =66） and ineffective group （n=24） according to their efficacy.The clinical data and levels of NF-kB，IL-17 and CXCR1 before treatment were analyzed and compared between the two group. MultivariateLogisticregressionanalysis wasused toanalyze thefactorsaecting thetherapeuticeffectofchildren with CAP.Receiver operating characteristic （ROC） curves were used to evaluate the eficacy of NF-kB，IL-17，and CXCR1 alone and in combination to predict the eficacyof children receiving piperacilin/tazobactam for CAP. ResultsBeforetreatment，there were statisticallsignificantdiffrencesinNF-kB[（22.5±6.6）ng/Lus.（31.8±8.2）ng/ L， t： =5.570，P<0.001]，IL-17 （23.5±2.4 vs.27.2±2.4， t =6.539， P <0.001）， CXCR1[（54.2±11.2）pg/ml vs. （69.3±11.4）pg/ ml， t=5.616， P <0.001]， and age （ χ2 =11.080， P =0.004） between the two groups.NF-kB [OR（95%CI）=2.328（1.086， 4.990），P=0.030]，I-17[OR（95%CI）=5.691（1.206，0.796），P=0.017]，CXCR1[OR（95%CI）=5.691（1.314，7.063） 0.009] and age <3 years before treatment [OR（95%CI）=2.328（1.085，4.997），P=0.030] were independent factors affectingthe efcacyof children receiving piperacillin/tazobactam for CAP;thearea under theROC curve（AUC）of NF- κ B， IL-17，and CXCR1 before treatment were 0.804，0.862，0.830，and 0.977，respectively，for predicting the effcacyof piperacilin/tazobactam inchildren treated with CAP.ConclusionCombinedNF-kB，IL-17，and CXCR1 levels before treatment predict the eficacy of children receiving piperacilln/tazobactam for CAP.

【Key words】 Community acquired pneumonia; Children；Nuclear factor-KB; Interleukin-17； Chemokinereceptor 1

DOI：10.19522/j.cnki.1671-5098.2025.03.010

社區(qū)獲得性肺炎（communityacquired pneumonia，CAP）主要由細(xì)菌、病毒及支原體等多種感染所致，是我國5歲以下兒童主要致死的呼吸系統(tǒng)疾病之一[]。（剩余5020字）