穿刺液降鈣素在甲狀腺髓樣癌中的診斷價(jià)值

打開文本圖片集

Diagnostic value ofcalcitoninintheaspiration fluid for medullarythyroidcarcinoma

ZhangLirong，YangMeiyu，ZhengDengzi，KeNantian，ChenZejin

DepartmentofClinicalLaboratory，theSecondAffiliatedHospitalofFujianUniversityofTraditionalChinese

Medicine，F(xiàn)uzhou 350001，China

Corresponding author： Chen Zejin， Email： 185484765@qq.com

【Abstract】 Objective To explore the diagnostic value of calcitonin （CT）in the aspiration fluid for medullary thyroid carcinoma （MTC）.MethodsThedataof140patients whounderwentfine-needle aspirationbiopsy （FNAB） ofthyroidnodulesintheSecondAfiliated HospitalofFujian UniversityofTraditional ChineseMedicine from August2022 to July 2O24 were selected.Among them，30 patients pathologically diagnosed with MTC served as the MTC group. Meanwhile，55 patients with pathologically confirmed thyroid benign lesions during the same period were selectedas the benign control group，and 55 patients with papillary thyroid carcinoma（PTC）werechosen as the PTC control group.The calcitonin levels in the aspiration fluid of each group of patients were detected，and the correlations between them and the serum calcitonin levels as wellas the results of ultrasound，CTand other maging examinations were analyzed to explore the sensitivityand specificityof calcitonin in the aspiration fluid for the diagnosis of MTC.ResultsThe results showed that the calcitonin levels in the aspiration fluid of the MTC group were significantly higher than those of the benign control group and the PTC control group（ P <0.001），and therewas asignificant positive correlation between thecalcitoninlevels in theaspirationfluidand theserumcalcitonin levels （r=0.783， P<0.001 ）.Through testing，the sensitivity of the detection of calcitonin in the aspiration fluid for MTC reached 86.7% （26/30），the specificity was 96.4% （106/11O）. Conclusion This study indicates that the detection of calcitoninintheaspirationfluidisanefcientandaccuratediagnosticmethodforMTC.Itssensitivityand specificityare higherthanthoseof traditional diagnostic methods，anditissimple tooperateandcauses lesstrauma. It is expectedto become an important auxiliary means for the early diagnosis of medulary thyroid carcinoma.

【Key words】 Puncture examination; Calcitonin; Medullary thyroid carcinoma; Early diagnosisDOI：10.19522/j.cnki.1671-5098.2025.03.004

甲狀腺癌是內(nèi)分泌系統(tǒng)最常見的惡性腫瘤之一，其發(fā)病率呈現(xiàn)出逐年遞增的態(tài)勢(shì)，對(duì)人類健康構(gòu)成了極為嚴(yán)重的威脅[1]。（剩余6119字）